复方黄龙胶囊对凝血、纤溶功能的影响

Influence of Huanglong Capsule on Coagulation and Fibrinolytic Function

目的探讨复方黄龙胶囊的抗凝血、纤维蛋白溶解作用。方法按试剂盒说明书对复方黄龙胶囊进行动物活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)的测定。用常规方法测定体外凝血时间(CT)、血块溶解时间(BLT)、优球蛋白溶解时间(ELT)。采用纤维蛋白平板法测定复方黄龙胶囊纤溶活性。结果复方黄龙胶囊体内外能明显延长APTT,PT,TT;与对照组比较,大、小剂量给药组BLT及ELT明显缩短,差异均有统计学意义(P<0.05或P<0.01);在普通纤维蛋白平板和加热平板上能溶解纤维蛋白。结论复方黄龙胶囊具有抗凝作用,能直接溶解纤维蛋白。

Objective To study the anticogagulation and fibrinolytic effects of Huanglong Capsule. Methods The activated partial thrumboplastin time（APTT）,prothrombin time（PT）,thrombin time（TT）,clotting time（CT） and fibrinogen（Fib） content in animals were determined by the reagent kit according to the instruction book;the blood-clot lysis time（BLT） and euglobulin lysis test（ELT） were determined by the routine method and the fibrinolytic activity was determined by the fibrin plate method. Results Huanglong Capsule could obviously prolong APTT, PT and TT in vitro, and decreased the Fib content. Compared with the normal saline control group, BLT and ELT in the large dose and small dose groups were significantly shortened with the statistical difference（P〈0. 05 or P〈0. 01）. Huanglong Capsule could dissolve fibrin on the common fibrin plate and heating plate. Conclusion Huanglong Capsule has obvious anticoagulation and fibrinolytic effect and can directly dissolve fibrin.