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干扰素调节因子的研究进展 被引量：12

Research Progress on the Interferon Regulatory Factor
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摘要 指出了干扰素调节因子(IRFs)是一类在干扰素(IFN)信号通路中起重要调控作用的多功能转录因子,目前已经发现10个IRFs成员,它们在IFN的诱导、病毒防御、免疫调节、细胞分化、细胞生长与凋亡和许多疾病的调节中具有重要作用.对IRFs的结构、IRFs在免疫系统、细胞分化、细胞凋亡和相关疾病如肿瘤、系统性红斑狼疮中的功能作了综述. Interferon regulatory factors （IRFs） consist of a family of transcription factors with diverse functions in the regulation of interferon signal pathways. Ten IRFs members have been identified so far, and they play a crucial role in regulating IFN induction, virus defense, immunomodulation, cell differentiation, cell growth and apoptosis and lots of diseases. This article summarized the structure of IRFs and their function in immune system , cell differentiation, cell apoptosis and related diseases such as tumor and systemic lupus ervthematosus （SLE）.
作者 沈金花 吕印 刘庆华
机构地区 中南民族大学生命科学学院医学生物研究所
出处 《中南民族大学学报（自然科学版）》 CAS 2014年第2期41-44,共4页 Journal of South-Central University for Nationalities：Natural Science Edition
基金 湖北省自然科学基金重点资助项目(2012FFA028)
关键词 干扰素调节因子 功能 疾病 interferon regulatory factor function disease
分类号 R392 [医药卫生—免疫学]
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参考文献24

  • 1Zhang R, Chen K, Peng L, et al. Regulation of T helper cell differentiation by interferon regulatory factor family members[J]. Immunol Res, 2012,54(1/3) :169-176.
  • 2Savitsky D,Tamura T,Yanai H,et al. Regulation of immunity and oncogenesis by the IRF transcription factor family [ J ]. Cancer Immunol Immun, 2010,59(4):489-510.
  • 3Saha B, Jyothi Prasarma S, Chandrasekar B, et al. Gene modulation and immunoregulatory roles of interferon gamma [J]. Cytokine, 2010,50(1):1-14.
  • 4Wang H, Morse H C 3rd. IRF8 regulates myeloid and B lymphoid lineage diversification [ J ]. Immunol Res, 2009,43 (1/3) :109-117.
  • 5Stark G R, Darnell J E Jr. The JAK-STAT pathway at twenty [J]. Immunity, 2012,36(4) :503-514.
  • 6Kaku H, Rothstein T L. Fas apoptosis inhibitory molecule expression in B ceils is regulated through IRF4 in a feed- forward mechanism [ J ]. J Immunol, 2009, 183 ( 9 ) : 5575-5581.
  • 7Zheng Y, Chaudhry A, Kas A, et al. Regulatory T-eell suppressor program co-opts transcription factor IRF4 to control T (H) 2 responses [ J ]. Nature, 2009,458 ( 7236 ) : 351-356.
  • 8Ouyang X, Zhang R, Yang J, et al. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation[J]. Nat Commun, 2011,2:314.
  • 9Yanai H, Negishi H, Taniguehi T. The IRF family of transcription factors: Inception, impact and implications in oncogenesis [ J ]. Oncoimmunology, 2012,1 (8) : 1376-1386.
  • 10Narayan V, Halada P, Hernychova L, et al. A muhiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1 [ J ]. J Biol Chem, 2011,286(16) :14291-14303.

同被引文献105

  • 1林勇,卢其西,杨慧赞,陈忠,黄姻,甘西,曾兰,唐章生.八种品系罗非鱼及其尼奥罗非鱼耐寒性能的比较试验[J].华北农学报,2011,26(S1):278-282. 被引量：13
  • 2朱佳杰,周宇,沈夏霜,李莉,罗永巨,甘西.吉富品系尼罗罗非鱼抗病性状分子标记筛选及遗传多样性分析[J].华北农学报,2013,28(S1):16-21. 被引量：4
  • 3徐国萍,李清泉,曹汐汐,陈琦,赵仲华,刁自强,许祖德.Smad7对转化生长因子β1诱导的肺泡上皮细胞向间质细胞转变的影响[J].中华医学杂志,2007,87(27):1918-1923. 被引量：7
  • 4María del Carmen Velarde-Ochoa,Jorge Antonio Esquivel-Valerio,et al.Anti-müllerian hormone in reproductive age women with systemic lupus erythematosus[J].Reumatología Clínica(English Edition),2015,11(2):78-82.
  • 5Shen JH, Lv Y, Liu Q H. Research progress on the interferon regulatory factor[ J]. J South- Central Univ Nationalities Nat Sci Ed) , 2014, 33 ( 2 ) : 41-44.
  • 6Zhao G N, Jiang D S, Li H. Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease [ J]. Biochim Biophys Aeta, 2015, 1852(2) : 365-378.
  • 7Li L, Xia H, Wang X, et al. Research progress in the interferon regulatory factor and cardiovascular disease [ J ]. Chin J Cardiovasc Res, 2015, 13 (3) : 193-197.
  • 8Zhang X J, Jiang D S, Li H. The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases [J]. Br J Pharmacol, 2015, 172(23): 5457-5476.
  • 9Honda K, Takaoka A, Taniguchi T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors[J]. Immunity, 2006, 25(3): 349 - 360.
  • 10Takaoka A, Yanai H. Interferon signalling network in innate defenee[J]. Cell Microbiol, 2006, 8(6): 907-922.

引证文献12

二级引证文献27

中南民族大学学报（自然科学版）
2014年 第2期

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