云南省红河州哈尼族和彝族妇女人乳头瘤病毒感染状况分析

The genotype distribution characteristics with HPV infected of Hani minority and Yi nationality women

目的调查研究红河州哈尼族、彝族妇女人乳头瘤病毒(HPV)分型分布情况。方法采用核酸分子快速导流杂交基因芯片技术(HybriMax)对宫颈脱落细胞进行HPV基因分型及细胞学涂片,结果异常者行宫颈活检。结果哈尼族妇女338例,HPV阳性106例(31.36%);单一亚型感染占80.19%,彝族妇女186例,HPV阳性56例(30.11%);单一亚型感染占82.14%。其中HR-HPV16感染率最高(哈尼族29.25%,彝族32.14%),其次为HR-HPV52(哈尼族26.42%,彝族19.64%)和HR-HPV53(哈尼族13.21%,彝族16.07%)。两民族各年龄段HPV感染率差异无统计学意义(P>0.05)。结论本地区哈尼族、彝族妇女HPV感染率较全国平均水平高,以高危型HPV16型感染为主,多为单一亚型感染,各年龄段妇女均易感,HPV检测结合细胞学和病理学检查,对筛查宫颈癌高风险人群及宫颈癌患者更为准确、安全、快捷。

ObjectiveTo investigate the distribution of HPV subtype in the Hani and Yi women of Yunnan province. Methods Specimens of cervical exfoliated cells were detected for HPV subtype by using nucleic acid flow-through hybridization, smearing cytological examination and underwent colposcopy cervical biopsy only for women of abnormal cytology test results.Results There were 106 patients of HPV positive in 338 cases Hani minority women（31.36%）. The single subtype infection rate of HPV was accounted for 80.19%. HR-HPV16 infection rate was the highest（29.25%）, followed by HR-HPV52（26.42%） and HR-HPV53（13.21%）. There were 56 patients of HPV positive in 186 cases Yi nationality women（30.11%）. A single subtype infection rate of HPV was accounted for 82.14%. HR-HPV16 infection rate was the highest（32.14%）, followed by HR-HPV52（19.64%） and HR-HPV53 （16.07%）. The different of the HPV infection rate was not significant in the all ages from Hani minority and Yi nationality women（P〉0.05）.Conclusions The HPV infection rates among the Hani and Yi women were higher than the national average level. The subtype in high-risk HPV16 infection rate was given priority to. Most of patients with HPV positive were a single subtype infection and different age groups of women were susceptible.HPV detection combined with cytology and pathology examination for patients with high-risk population and cervical cancer screening for cervical cancer were more accurate, safe and fast.