锌指蛋白A20与心血管疾病的研究进展

Progress in zinc finger protein A20 and cardiovascular disease

A20是一种同时具有去泛素化酶和泛素连接酶活性的锌指蛋白,在肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、脂多糖(LPS)等炎症因子刺激下快速大量表达。近来研究表明,A20参与多种心血管疾病的发生发展,本文就A20的起源与结构,A20的生物学功能以及它在血管成形术后再狭窄、动脉粥样硬化、心肌梗死后心力衰竭、心肌炎等心血管疾病中作用的研究进展作一综述,进一步对其深入研究可望为心血管疾病的预防和治疗提供新策略。

A20 is a zinc finger protein with both de-ubiquitination enzyme and ubiquitin ligase activity. It is rapidly abundantly expressed under stimulation of inflammatory factors such as tumor necrosis factor-α （TNF-α）, interleukin-1 （IL-1）, and lipopolysaccharide （LPS）. Recent studies have shown that A20 is involved in the development of a variety of cardiovascular diseases. This article summarized the origin, structure and its biological functions of A20. Finally, the role of A20 in the development of the restenosis after angioplasty, atherosclerosis, heart failure after myocardial infarction, myocarditis were also reviewed. Further studies will provide new strategies for the prevention and treatment of cardiovascular diseases.