肺结核患者血清IL-17A和IL-17F检测及临床意义

Expression and clinical significance of serum IL-17A and IL-17F on patients with pulmonary tuberculosis

目的研究肺结核（PTB）患者血清IL-17A和IL-17F含量并分析其临床意义。方法ELISA检测47例PTB患者和26名健康志愿者外周血血清IL-17A和IL-17F含量，并分析其相关性。结果PTB患者血清IL-17A含量显著高于健康志愿者。PTB患者和健康志愿者两组之间血清IL-17F含量无显著性差异。常规化疗药物治疗前PTB患者血清IL-17A含量显著高于治疗后。痰涂结核菌反应阳性PTB患者血清IL-17A和IL-17F含量显著高于阴性PTB患者。PTB患者血清IL-17A含量与患者性别、年龄均无关。血清IL-17F含量与患者治疗情况、患者性别及年龄均无明显相关。Pearson相关性分析显示，血清IL-17A和IL-17F含量之间无显著相关性。结论IL-17A和IL-17F均在抗结核免疫过程中发挥重要作用。

Objective To study serum IL-17A and IL-17F contents and analyse its clinical significance in pulmonary tuberculosis （PTB） patients. Methods ELISA was used to detect serum IL-17A and IL-17F contents on 47 PTB patients and 26 healthy volunteers （HV）. Pearson correlation analysis was used to analyze the correlation of them. Results Serum IL-17A hut not IL-17F level of PTB patients wassignificantly higher than that in HV group （ P 〈0.05）. And serum IL-17A but not IL-17F level of PTB patients was significantly decreased after treatment. Serum IL-17A and IL-17F levels of sputum smearpositive PTB patients were significantly higher than those in sputum smear-negative PTB patients. There was no significant correlation of serum IL-17A and IL-17F contents with patient gender or age. Thecorrelation analysis showed that there was no correlation between serum IL-17A and IL-17F levels in PTB patients. Conclusions IL-17A and IL-17F may play a more important role in PTB development.