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关注临床前期阿尔茨海默病的诊断:脑脊液生物标记物的价值 被引量：2

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摘要 阿尔茨海默病(AD)是老年期痴呆最常见的类型,随着时代的发展,AD将越来越严重威胁人类健康。早期积极干预对于延缓AD病程进展非常有意义。临床前期AD即未出现临床症状但已有AD病理生理改变的AD,其诊断必须依靠一些可靠的客观指标,目前研究最多的是脑脊液生物标记物,其中脑脊液tau蛋白和Aβ蛋白的高诊断价值已得到认可,还有很多其他正在研究之中的有价值的新生物标记物。要实现临床前期AD的诊断任重而道远,应从开展AD的全民知识普及做起。
作者 何志义
机构地区 中国医科大学附属第一医院神经内科
出处 《中华脑科疾病与康复杂志（电子版）》 2014年第3期1-3,共3页 Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
关键词 阿尔茨海默病 诊断 TAU蛋白质类 淀粉样Β蛋白 脑脊液
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献17

  • 1Alzheimer's Association. 2012 Alzheimer's disease facts and figures [J]. Alzheimers Dement,2012,8(2) :131-168.
  • 2McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer' s Disease [ J ]. Neurology, 1984,34 ( 7 ) : 939-944.
  • 3Widiger TA. DSM-1VSourcebook [ M ]. America: American Psychiatric Publishing, 1994.
  • 4Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preelinical stages of Alzheimer's disease:Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer' s disease [ J ]. Alzheimers Dementia,2011,7 (3) :280-292.
  • 5Blennow K, Hampal H, Weiner M, et al. Cerebrespinal fluid and plasma biomarkers in Alzheimer disease[ J]. Nat Rev Neuro1,2010, 6(3) :131-144.
  • 6Blom ES, Giedraitis V, Zetterberg H, et al. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/ epsilon4 genotype [ J ]. Dement Geriatr Cogn Diserd, 2009,27 ( 5 ) :458 -464.
  • 7Otto M, Wilt:fang J,Tumani H,et al. Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [ J ]. Neurosci Lett,1997,225(3) :210-212.
  • 8Buerger K, Ewers M,Pirttila T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease[J]. Brain,2006,129(Pt 11 ) :3035-3041.
  • 9Strozyk D, Blennow K, White LR, et al. CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study[J]. Neurology,2003,60(4) :652-656.
  • 10Tapiola T, Alafuzoff I, Herukka SK, et al. Cerebrospinal fluidf beta t -amyloid 42 and tan proteins as biomarkers of Alzheimer-type pathologic changes in the brain [ J ]. Arch Neurol, 2009,66 ( 3 ) : 382 - 389.

二级参考文献17

  • 1Alzheimer's Association. 2012 Alzheimer's disease facts and figures [J]. Alzheimers Dement,2012,8(2) :131-168.
  • 2McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer' s Disease [ J ]. Neurology, 1984,34 ( 7 ) : 939-944.
  • 3Widiger TA. DSM-1VSourcebook [ M ]. America: American Psychiatric Publishing, 1994.
  • 4Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preelinical stages of Alzheimer's disease:Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer' s disease [ J ]. Alzheimers Dementia,2011,7 (3) :280-292.
  • 5Blennow K, Hampal H, Weiner M, et al. Cerebrespinal fluid and plasma biomarkers in Alzheimer disease[ J]. Nat Rev Neuro1,2010, 6(3) :131-144.
  • 6Blom ES, Giedraitis V, Zetterberg H, et al. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/ epsilon4 genotype [ J ]. Dement Geriatr Cogn Diserd, 2009,27 ( 5 ) :458 -464.
  • 7Otto M, Wilt:fang J,Tumani H,et al. Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [ J ]. Neurosci Lett,1997,225(3) :210-212.
  • 8Buerger K, Ewers M,Pirttila T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease[J]. Brain,2006,129(Pt 11 ) :3035-3041.
  • 9Strozyk D, Blennow K, White LR, et al. CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study[J]. Neurology,2003,60(4) :652-656.
  • 10Tapiola T, Alafuzoff I, Herukka SK, et al. Cerebrospinal fluidf beta t -amyloid 42 and tan proteins as biomarkers of Alzheimer-type pathologic changes in the brain [ J ]. Arch Neurol, 2009,66 ( 3 ) : 382 - 389.

共引文献1

同被引文献27

  • 1Alzheimer's Association. 2012 Alzheimer's disease facts and figures [J]. Alzheimers Dement,2012,8(2) :131-168.
  • 2McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer' s Disease [ J ]. Neurology, 1984,34 ( 7 ) : 939-944.
  • 3Widiger TA. DSM-1VSourcebook [ M ]. America: American Psychiatric Publishing, 1994.
  • 4Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preelinical stages of Alzheimer's disease:Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer' s disease [ J ]. Alzheimers Dementia,2011,7 (3) :280-292.
  • 5Blennow K, Hampal H, Weiner M, et al. Cerebrespinal fluid and plasma biomarkers in Alzheimer disease[ J]. Nat Rev Neuro1,2010, 6(3) :131-144.
  • 6Blom ES, Giedraitis V, Zetterberg H, et al. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/ epsilon4 genotype [ J ]. Dement Geriatr Cogn Diserd, 2009,27 ( 5 ) :458 -464.
  • 7Otto M, Wilt:fang J,Tumani H,et al. Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [ J ]. Neurosci Lett,1997,225(3) :210-212.
  • 8Buerger K, Ewers M,Pirttila T, et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease[J]. Brain,2006,129(Pt 11 ) :3035-3041.
  • 9Strozyk D, Blennow K, White LR, et al. CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study[J]. Neurology,2003,60(4) :652-656.
  • 10Tapiola T, Alafuzoff I, Herukka SK, et al. Cerebrospinal fluidf beta t -amyloid 42 and tan proteins as biomarkers of Alzheimer-type pathologic changes in the brain [ J ]. Arch Neurol, 2009,66 ( 3 ) : 382 - 389.

引证文献2

二级引证文献3

中华脑科疾病与康复杂志（电子版）
2014年 第3期

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