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趋化因子CXCL12在缺血性脑卒中的作用及其机制 被引量：12

The role and mechanism of chemokine CXCL12 in ischemic stroke
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摘要 趋化因子CXCL12及其受体CXCR4参与炎症反应、诱导细胞迁徙和归巢等多种生理和病理过程,且与神经的产生、内分泌及变性等均密切相关。动物实验及临床研究证明,CXCL12及其传导通路在缺血性脑卒中不同时期具有加重损伤及促进功能重建的双重作用,有可能成为预测缺血性脑卒中近期发作及预后的一个新的生物学指标,为脑卒中预防及治疗开创新的途径。 Chemokine CXCL12 and its receptors are participated various pathological and physiological processes, such as participated in the inflammatory response and induced cell migration and homing,etc. Moreover, CXCL12 are closely related to the generation, endocrine and degeneration of neural system,etc. Animal experiments and clinical studies have demonstrated that CXCL12 and its pathway have aggravated the injury and promotes reconstruction in the dual role of different periods of ischemic stroke, there is likely to be a new biology indicator to predict recent onset and prognosis of ischemic stroke, and to inaugurate a new way for prevention and treatment of stroke.
作者 肖新兴 刘庆新
机构地区 滨州医学院附属医院神经内科
出处 《中华脑科疾病与康复杂志（电子版）》 2014年第3期45-48,共4页 Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金 山东省医药卫生科技发展计划项目(2013wso309)
关键词 趋化因子CXCL12 受体 CXCR4 卒中 机制 Chemokine CXCL12 Receptors,CXCR4 Stroke Mechanism
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献29

  • 1Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2011 update :a report from the American Heart Association [ J ]. Circulation, 2011,123 (4) : e1 8-e209.
  • 2Wang Y,Huang J,Li Y,et al. Roles of chemokine CXCL12 and its receptors in isehemic stroke [ J ]. Curt Drug Targets, 2012,13 ( 2 ) : 166-172.
  • 3Jaerve A, Muller HW. Chemokines in CNS injury and repair[ J]. Cell Tissue Res,2012,349 ( 1 ) :229-248.
  • 4Heinisch S, Palma J, Kirby LG. Interactions between chemokine and muopioid receptors: anatomical findings and electrophysiological studies in the rat periaqueductal grey [ J]. Brain Behav Immun, 2011,25(2) :360-372.
  • 5Liekens S, Schols D, Hatse S. CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization [ J ]. Curt Pharm Des, 2010, 16(35) :3903-3920.
  • 6Sun X,Cheng G, Hao M, et al. CXCL12/CXCR4/CXCR7 ehemokine axis and cancer progression [ J ]. Cancer Metastasis Rev, 2010, 29 ( 4 ) : 709-722.
  • 7Berger O, Li G, Han SM, et al. Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus [ J ]. Dev Neurosei ,2006,29(1/2) :48-58.
  • 8Li M, Ransohoff RM. Multiple roles of ehemokine CXCL12 in the central nervous system:a migration from immunology to neurobiology [J]. Prog Neurobiol,2008,84(2) :116-131.
  • 9Schutt RC, Burdick MD, Stricter RM, et al. Plasma CXCLI 2 levels as a predictor of future stroke[ J]. Stroke,2012,43 (12) :3382-3386.
  • 10Abi-Younes S, Sauty A, Mach F, et al. The stromal cell-derived faetor-i ehemokine is a potent platelet agonist highly expressed inatherosclerotic plaques [ J ]. Circ Res,2010,86 ( 2 ) : 131-138.

二级参考文献29

  • 1Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2011 update :a report from the American Heart Association [ J ]. Circulation, 2011,123 (4) : e1 8-e209.
  • 2Wang Y,Huang J,Li Y,et al. Roles of chemokine CXCL12 and its receptors in isehemic stroke [ J ]. Curt Drug Targets, 2012,13 ( 2 ) : 166-172.
  • 3Jaerve A, Muller HW. Chemokines in CNS injury and repair[ J]. Cell Tissue Res,2012,349 ( 1 ) :229-248.
  • 4Heinisch S, Palma J, Kirby LG. Interactions between chemokine and muopioid receptors: anatomical findings and electrophysiological studies in the rat periaqueductal grey [ J]. Brain Behav Immun, 2011,25(2) :360-372.
  • 5Liekens S, Schols D, Hatse S. CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization [ J ]. Curt Pharm Des, 2010, 16(35) :3903-3920.
  • 6Sun X,Cheng G, Hao M, et al. CXCL12/CXCR4/CXCR7 ehemokine axis and cancer progression [ J ]. Cancer Metastasis Rev, 2010, 29 ( 4 ) : 709-722.
  • 7Berger O, Li G, Han SM, et al. Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus [ J ]. Dev Neurosei ,2006,29(1/2) :48-58.
  • 8Li M, Ransohoff RM. Multiple roles of ehemokine CXCL12 in the central nervous system:a migration from immunology to neurobiology [J]. Prog Neurobiol,2008,84(2) :116-131.
  • 9Schutt RC, Burdick MD, Stricter RM, et al. Plasma CXCLI 2 levels as a predictor of future stroke[ J]. Stroke,2012,43 (12) :3382-3386.
  • 10Abi-Younes S, Sauty A, Mach F, et al. The stromal cell-derived faetor-i ehemokine is a potent platelet agonist highly expressed inatherosclerotic plaques [ J ]. Circ Res,2010,86 ( 2 ) : 131-138.

共引文献11

同被引文献105

引证文献12

二级引证文献70

中华脑科疾病与康复杂志（电子版）
2014年 第3期

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