期刊文献+

表观遗传标志物在前列腺癌中当前及未来的应用情况

下载PDF
导出
摘要 前列腺癌在西方国家是男性最常见的恶性肿瘤。从全球范围来讲,它是男性肿瘤的第2常见病及肿瘤致死的第6大原因。前列腺癌的发生与家族史、种族、肥胖、饮食习惯及其他环境因素有关,然而80岁的男性前列腺癌的估计发生率约为80%,其最确定性的危险因素是年龄。在当今老龄化社会,前列腺癌已成为全球性的健康问题,并造成了严重的经济负担。
出处 《浙江临床医学》 2014年第7期1165-1167,共3页 Zhejiang Clinical Medical Journal
  • 相关文献

参考文献29

  • 1AJemal, F, Bray, MM. Center,et al,Global cancer statistics.CA,2011, 61(2): 69-90.
  • 2Schroder F H,Hugosson J,Roobol M J,et al.Screening and prostate- cancer mortality in a randomized European study.New England Journal of Medicine,2009,360(13): 1320-1328. .
  • 3Cui M, Wen Z, Chen J, et al. 5-Aza-2' deoxycytidine is a potent inhibitor ofDNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation ofhMLH1.Medical Oncology, 2010,27(2): 278-285.
  • 4A.S.Perry,R.Foley,K.Woodson,et al,The emerging roles of DNA methylation in the clinical management of prostate cancer,Endocr.Rel. Cancer 2006,13:357-377.
  • 5Esteller M.Epigenetics in cancer.New England Journal of Medicine, 2008, 358(11): 1148-1159.
  • 6Mellor J. Dynamic nucleosomes and gene transcription.Trends in Genetics, 2006, 22(6): 320-329.
  • 7Matzke M A,Birchler J A.RNAi-mediated pathways in the nucleus. Nature Reviews Genetics,2005,6(1): 24-35.
  • 8Garzon R,Liu S,Fabbri M,et al.MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.Blood,2009,113(25): 6411-6418.
  • 9Weber B,Stresemann C,Brueckner B,et al.Methylation of human microRNA genes in normal and neoplastic cells.Cell cycle,2007,6(9): 1001-1005.
  • 10Dobosy J tk, koberts J LW, Fu V X,et al.The expanding role of epigenetics in the development,diagnosis and treatment of prostate cancer and benign prostatic hyperplasia.The Journal of urology,2007, 177(3): 822-831.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部