低氧通过HIF-2α诱导CCNE2表达的初步研究

Study on Hypoxia Induced the Expression of CCNE2 by HIF-2α

低氧是肿瘤发生侵袭转移必经的过程之一,它促进了肿瘤致癌基因的表达,从而使肿瘤细胞发生远处转移.低氧环境对于调节肿瘤的EMT过程具有重要作用,刺激肿瘤的恶化和转移,也可促进血管激活因子的表达从而促进肿瘤血管的形成.CCNE2作为调节细胞周期的关键基因,在肿瘤发生和转移过程中的作用已经得到广泛研究,在多种癌细胞中都发现CCNE2蛋白是高表达的.为此在MCF-7细胞中通过一系列的实验证明了CCNE2是一个新的低氧靶基因,并证明了低氧通过刺激HIF-2α促进了CCNE2的表达.

Hypoxia is one of the process of tumorigenesis and tumor metastasis,it promotes the expression of tumors which promotes tumor cells distant metastasis. Hypoxia plays an important role in EMT process, which stimulates the degradation and metastasis of tumor,moreover,it promotes the expression of vascular activator to induce the formation of tumor blood vessels. As a key regulating in cell cycle genes,the role of CCNE2 in tumorigenesis and metastasis has been extensively studied,CCNE2 is found to express more than normal cells in various cancer cells. For these,a series of experiments are done to demonstrate CCNE2 is a new target to hypoxia and hypoxia induces the expression of CCNE2 by HIF-2α.