猪240日龄GLU和GSP含量的全基因组关联分析

Whole-genome Association Studies on GLU and GSP Contents of 240-day Old Pig

试验采集了435头240日龄苏太猪和760头240日龄白色杜洛克×二花脸F2资源家系猪的血清以检测其血糖和糖基化血清蛋白指标,并利用Illumina porcine 60 K SNP芯片判定个体的基因型,同时进行了全基因组SNP与2个性状关联性分析,以及定位影响苏太猪和白色杜洛克×二花脸F2资源家系猪个体240日龄血糖和糖基化血清蛋白的QTL。结果表明,试验共定位到5个影响血糖和糖基化血清蛋白的QTL,且均为5%染色体显著水平,但其中2个可能是假阳性结果,这些QTL位于不同染色体区域,解释表型变异为3.719%和3.724%。

Four hundreds and thirty-fine 240-day old Sutai pigs and 760 240-day old white Duroc×Erhualian F2 pigs were killed, and serum were collected to detect blood glucose and glycation serum protein （GSP）; individuals＇ genotype was identified by using Illumina porcine 60 K SNP chip; association analysis between whole-genome SNP and two traits were carried out; QTL location to affect blood glucose and GSP of Sutai pigs and white Duroe×Erhualian F2 pigs at 240 days old were carried out. Results showed that five QTL affecting blood glucose and GSP was located, all at 5% level, among them there were two false positive, and their QTL located in different chromosomal regions, and explained 3.719% and 3.724% of the phenotypic variance.