急性脑梗死患者颈动脉斑块与血清CRP脂蛋白(a)水平的关系

The Relationship between Carotid Artery Sclerosis and C-reactive Protein(CRP)and Lipoprotein(a)in Patients with Acute Cerebral Infarction

目的探讨血清C反应蛋白(CRP)、脂蛋白(a)水平与急性脑梗死患者颈动脉斑块的关系。方法 86例急性脑梗死患者根据颈动脉彩色多普勒超声检查结果分为无斑块组、稳定斑块组与不稳定斑块组,对比各组血清CRP及脂蛋白(a)水平。结果 86例患者中稳定斑块26例(30.2%),不稳定斑块37例(43.0%),无颈动脉斑块23例(26.7%);不稳定斑块组CRP及脂蛋白(a)显著高于其余2组(P<0.01),稳定斑块组显著高于无斑块组(P<0.01)。结论急性脑梗死与颈动脉粥样硬化斑块形成有着密切关系,血清CRP、脂蛋白(a)检测对于了解颈动脉斑块性质,急性脑梗死的预防以及降低致残率与病死率等方面均具有重要临床意义。

Objective To discuss the relationship between carotid artery sclerosis and CRP and Lipoprotein （a） in patients with acute cerebral infarction.Methods 86 patients with acute cerebral infarction were divided into no plaque group ,stable plaque group and unstable plaque group , and the levels of CRP and Lipoprotein （a ） were compared between the three groups.Results There were 26 （30.2% ） patients with stable plaque ,37 （43.0% ） patients with unstable plaque ,and 23 （26.7% ） patients without plaque ,there was no significantly difference in age ,gender ,and disease time between the three groups（P〉0.05）.Levels of CRP and Lipoprotein（a） in unstable plaque group were significantly higher than those of the other two groups（P〈0.01） ,and they were significantly higher in stable plaque group than in no plaque group （P〈0.01）.Conclusion Acute cerebral infarction and carotid atherosclerosis plaque formation have closely relationship ,detection of serum CRP ,lip-oprotein （a） has important significance in finding the nature of plaque of carotid atherosclerosis ,prevention of acute cerebral in-farction and reducing morbidity and mortality.