帕罗西汀对急性脑梗死后抑郁患者神经功能缺损的影响

Influence of paroxetine on neurological deficit of patient with depression after acute cerebral infarction

目的探讨帕罗西汀对急性脑梗死后抑郁患者神经功能缺损的影响。方法将合并抑郁障碍的脑梗死患者80例随机分为观察组(盐酸帕罗西汀治疗组)和对照组(常规治疗组)。于治疗前及治疗后对2组分别采用汉密顿焦虑量表(HAMA)及神经功能缺损量表评定。结果 2组治疗前HAMD评分比较差异无统计学意义(P>0.05),治疗4周和8周后,观察组患者HAMD评分均明显低于对照组,差异具有统计学意义(P<0.05)。2组治疗前神经功能缺损评分比较差异无统计学意义(P>0.05),治疗后,观察组患者神经功能缺损评分明显低于对照组,差异具有统计学意义(P<0.05)。结论帕罗西汀可明显改善脑梗死后抑郁程度,并能促进神经功能恢复。

Objective To explore the effect of paroxetine on neurological deficit of patients with depression after acute cer-ebral infarction .Methods 80 patients were randomly divided into two groups ,the hydrochloride paroxetine treatment group and the control group .The clinical efficacy and side effects were assessed using Hamilton Anxiety Scale （HAMA） ,the Modified Neurologic Severity Scores （MNSS） before and after treatment .Results The Hamilton Anxiety Scale of the two groups had no statistically significant difference ,the Hamilton Anxiety Scale of the treatment group were statistically lower than that of the control group at the ends of 4 and 8 weeks treatment ,the difference was statistically significant （P〈0 .05） .the neurological def-icit score of the two groups had no statistically significant difference ,but the neurological deficit score of the treatment group were statistically lower than that of the control group at the end of 8 weeks of treatment .Conclusion Paroxetine could signifi-cantly improve the symptoms of depression after acute cerebral infarction ,and promote neurological rehabilitation .