齐拉西酮与利培酮治疗青年女性精神分裂症的疗效及对代谢的影响

Effective comparison of ziprasidone and risperidone in young female patients with schizophrenia and the influence on metabolism

目的探讨齐拉西酮与利培酮治疗青年女性精神分裂症的临床疗效及对代谢的影响。方法将116例青年女性精神分裂症患者随机分为利培酮组与齐拉西酮组,分别接受利培酮及齐拉西酮治疗,疗程8周。比较2组临床疗效、不良反应及对代谢的影响。结果治疗8周后,2组阳性及阴性症状量表(PANSS)各项评分差异无统计学意义(P>0.05);利培酮组锥体外系症状、体质量增加、月经改变及泌乳等不良反应发生率显著高于齐拉西酮组(P<0.05);齐拉西酮组治疗前后BMI及泌乳素无显著变化,利培酮组治疗后上述指标显著高于齐拉西酮组(P<0.05)。结论齐拉西酮与利培酮治疗青年女性精神分裂症临床疗效相当,但齐拉西酮对代谢影响小,更适合青年女性的治疗。

Objective To compare the effectiveness of ziprasidone and risperidone in young female patients with schizo-phrenia and the influence on metabolism.Methods 116 young female patients with schizophrenia were randomly divided into zi-prasidone group and risperidone group.The two groups received ziprasidone and risperidone treatment respectively.The course of treatment was 8 weeks.Clinical effectiveness ,adverse reactions and the influence on metabolism were compared between the two groups.Results There were no significant difference of PANSS scores on 8 weeks after treatment between two groups （P 〉0.05）;The occurrence of extrapyramidal symptom ,weight gain and lactation and menstruation abnormality in risperidone group were much higher than those in ziprasidone group （P0.05）;Compared with ziprasidone group ,BMI and prolactin greatly increased in ris-peridone group （P〈 0.05）.Conclusion Ziprasidone and risperidone have equivalent effectiveness for young female patients with schizophrenia ,while ziprasidone is more favorable for young female patients for less influence on metabolism.