氟哌啶醇联合氯氮平治疗难治性精神分裂症的疗效观察

Efficacy of haloperidol combined with clozapine for refractory schizophrenia

目的探讨氟哌啶醇合并氯氮平治疗难治性精神分裂症的疗效以及安全性。方法选取我院100例难治性精神分裂症患者,平均分为观察组与对照组,观察组采用氟哌啶醇联合氯氮平治疗,对照组单一采用氯氮平治疗,并通过BPRS、CGI量表评定疗效,总疗程16周。结果前4周2组疗效差异不显著,总疗程结束后,观察组有效率明显高于对照组。观察组出现不良反应13例,对照组28例,且观察组震颤、月经紊乱、心电图异常等不良反应明显低于对照组,2组不良反应对比差异有统计学意义(P<0.05)。结论氟哌啶醇合并氯氮平治疗的有效率明显高于单一用药,且不良反应小,大大提高了治疗的安全性。

Objective To investigate the efficacy and safety of haloperidol combined with clozapine for refractory schizo-phrenia.Methods 100 cases of refractory schizophrenia in our hospital were divided into observation group and control group.the total treatment was 16 weeks ,observation group were treated with haloperidol combined with clozapine ,control group were given clozapine for treatment ,and the efficacy was evaluated by the BPRS ,CGI.Results the difference of the effica-cy of the two groups was not significant in the Four weeks of the treatment ;after the total course of treatment ,the efficiency of observation group was significantly higher than that of the control group.After treatment ,adverse reactions occurred in 13 cases of the observation group ,while adverse reactions occurred in 28 cases of the control group.the number of patients with tremors , menstrual disorders and abnormal electrocardiogram in the observation group was lower than that in the control group ,there was significantly difference （P〈0.05）.Conclusion the efficacy of haloperidol combined with clozapine is more obvious than clozapine alone ,and it can reduce the incidence of side effects and improve the safety greatly .