青阳参总甙对癫痫发作后脑损伤的神经保护作用的研究

Research on otophyllum glycosides right brain damge seizures neurroprotective role

目的:调查研究青阳参总甙对癫痫发作后脑损伤的神经保护的作用。方法:采用随机数字表法将120只雄性Wistar大鼠随机分成两组,分别为非癫痫组(20只)和癫痫组(100只),其中癫痫组又分为对照组、青阳参组、丙戊酸组和青阳参加丙戊酸组等四个亚组(各25只)。结果:青阳参加丙戊酸组治疗的总有效率为92%,与青阳参组的72%以及丙戊酸组的76%相比差异具有统计学意义(P<0.05)。癫痫组中对大鼠皮层海马内c-fos和c-jun的表达与对照组比较,差异有统计学意义(P<0.05)。结论:青阳参总甙与丙戊酸的抗癫痫效果最佳,可以有效地减少癫痫发作频率和减少脑组织的细胞凋亡,且安全性较高,值得在临床中进一步推广与使用。

Objective Research otophyllum glycosides right brain damage seizures neuroprotective role.Method By a random number table 120 male Wistar rats were randomly divided into two groups,namely non-epilepsy group （20） and the epilepsy group （100） ,in which epilepsy group was divided into control group,otophyllum group,valproic acid group and otophyllum ＋ valproic acid group such as 4 subgroups （each 25） .Results Otophyllum ＋ valproic acid treatment group,the total effective rate was 92%,with 72% of the group otophyllum and valproic acid group compared to 76%,there was a big difference,and the difference was statistically significant （P〈0.05） .Epilepsy group in the hippocampus of rat cortical c-fos and c-jun expression,there was a big difference compared with the control group （P〈0.05） .Conclusion Otophyllum glycosides and valproate antiepileptic best,can effectively reduce seizure frequency and brain cell apoptosis,and high security,it is worth further promotion and in clinical use.