脐血间充质干细胞移植治疗缺氧缺血性脑病研究进展被引量：1

导出

摘要新生儿缺氧缺血性脑病（hypoxic-ischemic encephalopathy,HIE）是指新生儿因围生期缺氧引起的脑部病变,是造成新生儿死亡和儿童脑瘫的主要原因之一。亚低温治疗可以阻止缺氧缺血对大脑组织的进一步损害[1],但仍有40%左右经过亚低温治疗的患儿死亡或遗留严重的神经系统损害。

作者唐华兵温晓红

机构地区安徽医科大学第三附属医院(合肥市第一人民医院)儿科

出处《中国新生儿科杂志》 CAS 2014年第4期284-287,共4页 Chinese Journal of Neonatology

基金安徽高校省级自然科学研究项目(KJ2012Z717) 合肥市科技局自主创新社会发展类专项资助项目(2013-25-9)

关键词新生儿缺氧缺血性脑病脐血间充质干细胞移植治疗神经系统损害新生儿死亡亚低温治疗围生期缺氧脑部病变

分类号 R722.1 [医药卫生—儿科]

引文网络
相关文献

参考文献26

1Azzopardi D, Strohm B, Edwards AD, et al. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed, 2009, 94: F260-264.
2Bertani N,Malatesta P, Volpi G, et al. Neurogenic potential of human mesenchymal stem cells revisited: analysis by immunostaining, time-lapse video and microarray. J Cell Sci, 2005,118 : 3925-3936.
3Bianco P,Gehron Robey P. Marrow stromal stem cells. J Clin Invest, 2000,105 : 1663-1668.
4Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest, 1999,103:697-705.
5Ball SG, Shuttleworth CA, Kielty CM. Platelet-derived growth factor receptors regulate mesenehymal stem cell fate : implications for neovaseularization. Expert Opin Biol Ther,2010,10:57-71.
6Park I-IW,Lim MJ,Jung H,et al. Human mesenchymal stem cell derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production,in a model of spinal cord injury. Glia,2010,58 : 1118-1132.
7van Velthoven CT, Kavelaars A, van Bel F, et al. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav Immun,2010,24 : 387- 393.
8Lu D, Sanberg PR, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant, 2002, 11 : 275- 281.
9Chen J, Li Y, Katakowski M, et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res,2003, 73:778-786.
10Van Velthoven CT, Kavelaars A, Van Bel F, et al. Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res Rev,2009,61 : 1-13.

二级参考文献56

1官晓清,余加林,李禄全,刘官信.骨髓间充质干细胞透过新生大鼠血脑屏障的实验研究[J].中华儿科杂志,2004,42(12):920-923. 被引量：18
2李禄全,余加林,官晓清,刘官信.鼠骨髓间充质干细胞在缺氧缺血性脑病新生鼠脑内的分布及分化[J].第三军医大学学报,2005,27(4):327-330. 被引量：10
3余勤,罗依,董勤,赵伟春,刘文洪,孙国金.黄芪对间质干细胞分化为神经元样细胞的定向诱导作用[J].中华急诊医学杂志,2004,13(12):826-829. 被引量：19
4余勤,连俊兰,王艳,郭莹,万海同.大鼠骨髓间质干细胞体外培养扩增及生物学特性研究[J].浙江中医药大学学报,2006,30(2):189-192. 被引量：18
5颜小华,陈晓.脐血间充质干细胞静脉移植治疗新生大鼠缺氧缺血性脑损伤[J].中国新生儿科杂志,2006,21(3):158-161. 被引量：11
6Mahmoodd,A,Lu D,Qu C,et al.Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats.J Neurosurg,2006,104:272-277.
7Liu Z,Li Y,Qu R,et al.Axonal sprouting into the denervated spinal cord and synaptic and postsynaptic protein expression in the spinal cord after transplantation of bone marrow stromal cell in stroke rats.Brain Res,2007,1149:172-180.
8Chen J,Sanbery PR,Li Y,et al.Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats.Stroke,2001,32:2682-2688.
9Zhao LR,Duan WM,Reyes M,et al.Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.Exp Neurol 2002,174:11-20.
10Chen J,Li Y,Wang L,et al.Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats.Stroke,2001,32:1005-1011.