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拉莫三嗪与卡马西平治疗原发性三叉神经痛的临床价值分析 被引量:11

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摘要 目的对原发性三叉神经痛治疗中卡马西平与拉莫三嗪的临床应用价值进行分析。方法选取我院于2011年9月至2013年8月诊治原发性三叉神经痛患者62例,随机分为两组,对照组30例给予卡马西平治疗,观察组32例给予拉莫三嗪治疗,对比两组患者治疗效果及疼痛消除情况。结果两组治疗总有效率间无显著差异,观察组完全缓解率显著高于对照组,治疗后疼痛VAS评分显著低于对照组;两组患者治疗期间均未发生严重不良反应,轻微不良反应发生率间无显著差异。结论在原发性三叉神经痛治疗中拉莫三嗪具有显著疗效,可对患者疼痛症状予以有效缓解,具有较高临床应用价值。
作者 胡媛
出处 《中国医药指南》 2014年第21期147-148,共2页 Guide of China Medicine
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  • 1Tolle T, Dukes E,Sadosky A.Patient burden of trigeminal neuralgia:results from a cross-sectional survey of health state impairment and treatment patterns in six European countries [J].PainPract,2006, 6(3): 153-160.
  • 2Brisman R. Gamma knife surgery with a dose of 75 to 76.8 Gray for trigeminal neuralgia[J].J Neurosurg,2004,100(5):848-854.
  • 3Jellish WS,Benedict W, Owen K,et al.Perioperative and long- term operative outcomes after surgery for trigeminal neuralgia: microvascular decompression vs percutaneous balloon ablation[J]. Head Face Med,2008,4:11.
  • 4Tneodosopoulos PV, Marco E, Applebury C, et al. Predictive model for pain recurrence after posterior fossa surgery for trigeminal neuralgia[J]. J Arch Neurol,2002,59(8): 1297-1302.
  • 5Sindou M,Leston J, Howeidy T, et al.Microvascular decompression for primary trigeminal neuralgia (typical or atypical): long-term effectiveness on pain; prospective study with survival analysis in a consecutive series of 362 patients[J]. Acta Neurochir (Wien),2006,148 ( 12): 1235-1245.
  • 6Sindou M, Mertens P. Microsurgical vascular decompression in trigeminal and glosso-vago-pharyngeal neuralgias. A twenty year experience [J]. Acta Neurochir Suppl (Wien), 1993,58:168 - 170.
  • 7Kondziolka D, Lunsford LD, Flickinger JC. Stereotactic radiosurgery for the treatment of trigeminal neuralgia[J]. Clin J Pain,2002,18 (1) :42-47.
  • 8Hasegawa T, Kondziolka D, Spiro R,et al.Repeat radiosurgery for refractory trigeminal neuralgia [J].Neurosurgery,2002,50(3 ):494-502.
  • 9Shaya M,Jawahar A,Caldito G,et al.Gamma knife radiosurgery for trigeminal neuralgia: a study of predictors of success, efficacy, safety, and outcome at LSUHSC[J].Surg Neurol,2004,61 (6):529-534.
  • 10Azar M,Taha YS,Bitaraf M,et al.Gamma knife radiosurgery in patients with trigeminal neuralgia: quality of life, outcomes, and complications [J].Clin Neurol Neurosurg,2009,111 (2): 174-178.

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  • 1刘维洲,汤正义.抗癫痫药物在神经性疼痛治疗中的应用[J].世界临床药物,2007,28(5):262-265. 被引量:8
  • 2叶广仁,宋志彬,郑国俊,廖卫平,易咏红.中国成年人拉莫三嗪药代动力学及丙戊酸对其影响[J].神经疾病与精神卫生,2007,7(3):191-193. 被引量:15
  • 3Leach M J, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action [J]. Epilepsia, 1986,27 (5) : 490-497.
  • 4LAMICTAL~ (lamotrigine) prescribing information EEB/ OL]. http://www.rxlist.corrdiamictal- ttrug.htm, 2014-2-25.
  • 5Walker MC, Tong X, Perry H, et al. Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine EJ]. Br J Pharmacol, 2000,130 (2) : 242-248.
  • 6Meyer F P, Banditt P, Schubert A, et al. Lamotrigine concentrations in human serum, brain tissue, and tumor tissue ~J]. Epilepsia, 1999,40 (1) :68-73.
  • 7Rambeck B, Jurgens UH, May TW, et al. Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy[J].Epilepsia, 2006,47 (4):681-694.
  • 8Rowland A, Elliot D J, Williams JA, et al. In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction [J]. Drug Metab Dispos, 2006, 34 (6) : 1055-1062.
  • 9Yamamoto Y, Inoue Y, Matsuda K, et al. Influence of concomitant antiepileptic drugs on plasma lamotrigine concentration in adult Japanese epilepsy patients [J]. Biol Pharm Bull, 2012,35 (4) :487-493.
  • 10Gillham R, Kane K, Bryant-Comstock L, et al. A double- blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure[J]. Seizure, 2000, 9 (6) : 375-379.

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