TIP30和骨桥蛋白在喉鳞状细胞癌中的表达及意义

Expression and clinical significances of TIP30 and OPN in laryngeal squamous cell carcinoma

目的探讨喉鳞状细胞癌组织中TIP30与骨桥蛋白(OPN)的表达及意义。方法应用免疫组织化学SP法检测60例喉鳞状细胞癌(A组)及癌旁组织(B组)TIP30与OPN的表达,分析TIP30表达与喉鳞状细胞癌临床病理特征的关系。结果 A组TIP30表达率低于B组(45.0%vs.78.3%)(P<0.05)。A组OPN表达率高于B组(73.3%vs.25.0%)(P<0.05)。TIP30蛋白的表达与临床分期、病理组织学分级和颈部淋巴结转移有关(P<0.05)。在喉鳞状细胞癌组织中,TIP30与OPN在蛋白水平的表达呈负相关(P<0.05)。结论 TIP30可能在喉鳞状细胞癌发生、发展和转移中起重要作用,可作为肿瘤标志物用于喉鳞状细胞癌临床诊断和预后判断。

Objective To investigate the expression and clinical significances of TIP30and osteopontin（OPN）in laryngeal squamous cell carcinoma（LSCC）.Methods The expressions of TIP30and OPN were detected by immunohistochemical SP method in 60LSCC specimens（group A）and tumor-adjacent normal tissues（group B）.The relationship between the expressions of TIP30and OPN and clinicopathological features of LSCC was analyzed.Results The positive expression rate of TIP30was lower in group A than that of group B（45.0% vs.78.3%）（P〈0.05）.The positive expression rate of OPN was higher in group A than that in group B（73.3% vs.25.0%）（P〈0.05）.The expression level of TIP30 was significantly correlated with tumor stage,grade and lymph node matastasis（P〈0.05）,but not correlated with age,gender and tumor primary site（P〉0.05）.The expression level of TIP30was negatively correlated to that of OPN in group A（P〈0.05）.Conclusion TIP30may play a important role in the development and metastasis of LSCC,and could be taken as a marker for clinical diagnosis and prediction of prognosis in the patients with LSCC.