支气管肺发育不良患儿肺功能变化的临床观察

A clinical observation on changes of pulmonary function in infants with bronchopulmonary dysplasia

目的观察支气管肺发育不良(BPD)患儿肺功能变化。方法采用婴幼儿体描箱检测并比较BPD患儿31例(A组)和40例健康婴幼儿(C组)达峰容积(VPEF)/呼气容积(VE)比值、达峰时间(TPTEF)/呼气时间(TE)比值、功能残气量(FRC)、有效气道阻力(Reff)、呼吸频率(RR)和每千克体重呼吸系统静态顺应性(Crs/kg)等肺功能指标。结果 A组VPEF/VE和TPTEF/TE比值、FRC和Crs/kg均低于C组,而Reff和RR高于C组(P<0.05)。两组其余肺功能指标相仿(P>0.05)。结论 BPD患儿均存在气道阻塞和肺功能下降。体描箱可作为检测BPD患儿肺功能的重要手段。

Objective To observe the changes of pulmonary function in the infants with bronchopulmonary dysplasia（BPD）.Methods The major indicators of pulmonary function were examined and compared between BPD infants（group A,31cases）and healthy infants（Group C,40cases）by plethysmogrophy,which included the ratio of peak volume to expiratory volume（VPEF/VE）,the ratio of the time reaching peak tidal flow to expiratory time（TPTEF/TE）,functional residual capacity（FRC）,respiratory rate（RR）,effective airway resistance（Reff）and respiratory static compliance per kilogram（Crs/kg）.Results The ratioes of VPEF/VE and TPTEF/TE,FRC and Crs/kg were lower,while Reff and RR were higher,in group A than those in group C（P〈0.05）.There were no significant differences in the rest of pulmonary function indicators between two groups（P〉0.05）.Conclusion Airway obstruction and lung function decline exist in BPD infants.Plethysmogrophy may be taken as a valuable tool in the examination of pulmonary function in BPD infants.