过敏性结膜炎泪膜改变与干眼症的相关性浅析

Analysis of the correlation between tear film changes of allergic conjunctivitis and dry eye

目的:研究过敏性结膜炎泪膜功能的变化与干眼症发生的相关性,以更好的指导临床治疗。方法:选取50例眼科门诊诊断为过敏性结膜炎的患者为观察组,按1∶1对照随机选取50例无眼表疾病、干眼症和全身疾病的健康人为对照组,分别进行角膜荧光素(FL)染色检查、泪膜破裂时间(BUT)、基础泪液分泌试验(SⅠt)、泪河线高度(TMH)测量和裂隙灯检查。结果:观察组左眼与右眼FL,SⅠt,BUT,TMH间存在相关性,差别有统计学意义(P<0.05);观察组与对照组患者FL、BUT评分差异有统计学意义(P<0.05);观察组患者中TMH与SⅠt间呈正相关,FL与BUT呈负相关,且差别均具有统计学意义(P<0.05)。结论:过敏性结膜炎可因炎症介质的介入引发泪膜稳定性变化,从而导致干眼症发生。过敏性结膜炎泪膜稳定性变化与角膜上皮损害程度相关。

AIM： To analyze the correlation between tear film changes of allergic conjunctivitis and dry eye, then provide clinical references for better treatment. METHODS： Fifty patients with allergic conjunctivitis were taken as the observation group, the control group was selected based on 1：1 case control theory, and we chose 50 health volunteers without ocular surface diseases, xerophthalmia and systematic diseases randomly, then fluorescein （FL） staining, break-up time （BUT）, Schirner Ⅰ test （S Ⅰ t）, tear meniscus high （TMH） and slit-lamp examinations were performed in the two groups. RESULTS： In the observation group, FL, BUT, Sit, TMH of right eyes and left eyes were statistically significant correlated （ P 〈 0. 05）. FL and BUT were statstically significant between control group and observation group （P〈0.05）. TMH and Sit has positive correlation, while FL and BUT has negative correlation and the differences were statistically significant （P〈0.05）. CONCLUSION： Due to inflammatory mediators participation, allergic conjunctivitis could lead to the stability changes of tear film which cause in dry eye. The stability changes of allergic conjunctivitis correlate to the damage degree of epithelium.