复方血栓通对NPDR激光光凝术后的视网膜血流动力学影响

Retinal hem odynam ic influence of compound xueshuantong capsule on nonproliferative diabetic retinopathy after laser photocoagulation

目的:观察复方血栓通对非增生性糖尿病性视网膜病变(nonproliferative diabetic retinopathy,NPDR)激光光凝术后的视网膜血流动力学的影响。方法:选取已行激光光凝术后的NPDR患者41例72眼,给予复方血栓通治疗,于治疗前后,采用彩色多普勒血流检测仪检测视网膜血流动力学情况。结果:治疗后患眼视网膜血流灌注有明显改善,视网膜中央动脉的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)和平均血流速度(Vm)均增高,而阻力指数(RI)降低,差异有统计学意义(P<0.05)。治疗后61眼视力改善,总有效率85%。治疗后视力提高值和患眼的PSV,Vm和RI的变化差值呈明显的相关性。结论:复方血栓通对NPDR激光光凝术后患者的视网膜血流灌注有明显改善,并且这种改善和患者视力预后的改善密切相关。

AIM. To observe retinal hemodynamic influence of compound xueshuantong capsule on nonproliferative diabetic retinopathy （NPDR） after laser photocoagulation. METHODS： A total of 41 patients （72 eyes） with NPDR after laser photocoagulation were enrolled in this study. They were all given compound xueshuantong capsule, and used color Doppler flow imaging for detection of retinal hemodynamics. RESULTS： After treatment, patients with retinal blood perfusion significantly improved; central retinal arterial peak systolic velocity （ PSV）, end - diastolic velocity （EDV） and medial velocity （Vm） were increased, while the resistance index （RI） decreased. The difference have statistical significance （ P〈 0.05）. The visual acuity of 61 eyes improved, efficiency was 85%. Visual acuity was related with PSV, Vm and RI. CONCLUSION： Compound xueshuantong capsule can improve retinal blood perfusion for nonproliferative diabetic retinopathy after laser photocoagulation, which is related to improvement of visual prognosis.