心脏乳头状弹力纤维瘤6例临床病理分析

Clinical and pathological analysis of cardiac papillary fibroelastoma

目的分析心脏乳头状弹力纤维瘤的临床病理学特征,为临床诊疗及判断预后提供依据。方法对我院10年间收治的6例心脏乳头状纤维瘤进行HE染色及弹力纤维EVG染色,回顾性分析其临床资料及病理学特征。结果肿瘤典型外观呈"海葵样"。镜下呈分支细乳头状,表面被覆一层内皮细胞。弹力纤维染色可见较多弹力纤维。术后随访3个月～8年,6例患者均恢复情况良好,无复发。结论心脏乳头状弹力纤维瘤非常罕见,为心脏原发性良性肿瘤,好发于心脏瓣膜上;其临床症状缺乏特异性,临床诊断困难,但其组织形态学的特征典型,病理学检查易诊断。

Objective To study the clinical and pathological characteristics of cardiac papillary fibroelastoma which could facilitate the diagnosis and treatment. Methods Six cases of cardiac papillary fibroelastoma which were treated in our hospital in the recent10 years were reviewed retrospectively. All the cases of cardiac papillary fibroelastoma were stained routinely by HE and an elastic stain.Results The typical tumor showed the appearance of sea anemone. It was coated by a layer of endothelial cells,and fine papillary branches can be observed under a microscope. There were some elastic fibers in the tumor. The patients were followed for 3 months to 8years,and no recurrence was observed. Conclusion Cardiac papillary fibroelastomas is rare,and it is a primary benign tumor of the heart valves. The clinical manifestations of cardiac papillary fibroelastoma are not characteristic,it is hard to diagnose according to clinical manifestations. But the tumor has typical histomorphological features,it can be diagnosed by pathological examination.