BINAL-H试剂的高手性识别能力

The BINAL-H Reagent Possessing Extremely High Ability of Chiral Recognition

本文主要介绍了日本名古屋大学化学系R.Noyori教授研究组发展起来的利用金属氢化物LiAlH4简称为(LAH)、轴手性(S)-或(R)-联萘酚与简单醇之间的反应制备新的手性氢化试剂BINAL-H。该还原剂具有极高的对映面识别能力且能够以可预测的和高光学产率地还原许多结构不同的不饱和羰基化合物。

This article mainly introduced a new chiral hydride reagent, BINAL- H, has been devised and de- veloped by the modification of lithium aluminum hydride with axially dissymmetric （S） -or （R） - binaphthol and a simple alcohol by professor R. Noyori in the department of chemistry of Nagoya University. This reducing agent possesses exceptionally high enantioface -differentiating ability and reduces a wide variety of structurally diverse unsaturated carbonyl substrates in high optical yields and in a predictable manner.