摘要
Sirtuins是第Ⅲ类组蛋白去乙酰化酶,主要成员SIRT1、SIRT6与慢性阻塞性肺疾病(COPD)发病机制有密切关系。SIRT1、SIRT6在COPD患者肺部中表达下调,并通过多种机制调节炎性反应、肺部自噬与衰老。Sirtuins可能是COPD发生过程中的一个调控分子家族。
Sirtuins are class Ⅲ histone deacetylase.SIRT1 and SIRT6 are the major members of Sirtuins participated in the development of chronic obstructive pulmonary disease（COPD）.The expression of SIRT1 and SIRT6 was down-regulated in the lungs of patients with COPD.They regulate inflammatory reaction,lung autophagy and senescence through multiple mechanisms.Sirtuins may be one of major regulatory molecule family in the progression of COPD.
出处
《基础医学与临床》
CSCD
北大核心
2014年第7期1010-1013,共4页
Basic and Clinical Medicine
