妈富隆与安宫黄体酮治疗绝经过渡期功血的疗效比较

Comparison of the therapeutic effects of marvelon and medroxyprogesterone on menopausal transitional dysfunctional uterine bleeding

目的:比较妈富隆与安宫黄体酮治疗绝经过渡期功血的治疗效果。方法:选取78例确诊为绝经过渡期子宫出血的患者,随机分为两组,每组39例,分别采用妈富隆治疗组和安宫黄体酮治疗组,比较两组控制出血时间、止血时间、复发率、纠正贫血及月经量方面的差异。结果:安宫黄体酮组控制出血时间为(43.50±8.15)h,妈富隆组控制出血时间为(25.34±4.49)h,两组比较差异具有统计学意义(P<0.05);安宫黄体酮组完全止血时间为(63.16±12.23)h,妈富隆组完全止血时间为(37.16+15.75)h,两组比较差异具有统计学意义(P<0.05);安宫黄体酮组的复发率为25.64%,妈富隆组复发率为5.13﹪,两组比较差异具有统计学意义(P<0.05);治疗后安宫黄体酮组与妈富隆组血红蛋白分别提高17.8 g/L与36.5 g/L,两组比较差异亦有统计学意义(P<0.05)。结论:妈富隆治疗绝经过渡期功血方法简单,安全性好,疗效显著,不良反应少。

Objective： To compare the therapeutic effects of marvelon and medroxyprogesterone on menopausal transitional dysfunctional uterine bleeding. Methods： Seventy-eight patients with menopausal transitional dysfunctional uterine bleeding were randomly divided into marvelon group and medroxyprogesterone group, with 39 cases in each group. The controlled time of bleeding symptom, hemostasis time, recurrence rate, the effect of correcting anemia and menstrual flow were compared between two groups. Results ： The controlled time of bleeding symptom of marvelon group and medroxyprogesterone group were （43.50 ± 8.15 ） h and （25.34 ± 4.49） h respective- ly; hemostasis of marvelon group and medroxyprogesterone group were controlled at （63. 16 ± 12.23） h and （37. 16 ± 15.75） h respectively; recurrence rates of marvelon group and me- droxyprogesterone group were 25.64% and 5. 13% respectively; the levels of hemoglobin after treatment in marvelon group and medroxyprogesterone group were respectively increased by 17.8 g/L and 36.5 g/L. The differences between two groups were statistically significant （P 〈 0.05）. Conclusion： The treatment with marvelon on menopausal transitional dysfunctional uterine bleed- ing had advantages such as simplicity, good safety, remarkable effects, less adverse reactions.