药物斑贴试验与药疹

Drug patch testing and drug eruption

药疹是指正常剂量的药物经过多种途径进入人体后引起的皮肤黏膜的损害,其病理生理学发病机制不明.药疹的临床表现多样,了解药疹的分类及发病机制对其诊断和寻找可疑致敏药物至关重要.药物斑贴试验的目的是寻找引起药疹的致敏药物,提供患者可能的致敏药物信息.近年来应用于临床的药物斑贴试验安全性较高、操作简便,为药疹的诊断提供了重要的依据.有关药物斑贴试验的相关研究较多,但结果不一.

Drug eruption refers to adverse reactions of skin and mucous membrane caused by the entry of drugs at normal doses into the human body through multiple ways.The pathophysiology of drug eruption is unclear.The manifestations of drug eruption are various.To learn the classification and pathogenesis of drug eruption is important for its diagnosis and identification of the culprit drug.The purpose of drug patch testing is to find drug allergens,and to provide patients with possible information about causative drugs.At present,the drug patch testing applied in clinical practice are relatively safe and convenient,which has offered an important basis for the diagnosis of drug eruption.There have been numerous studies on drug patch testing,but the results are varying and somewhat contradictory.