表皮生长因子受体抑制剂的皮肤不良反应及处理

Adverse skin reactions to epidermal growth factor receptor inhibitors and their management

表皮生长因子受体抑制剂已成为多种肿瘤生物靶向治疗的重要选择,在肿瘤治疗领域地位日益突出.其可引发多种皮肤不良反应,如：痤疮样皮疹,毛发改变,放射性皮炎,皮肤瘙痒、干燥和皲裂及口腔并发症、指趾甲的改变等.认识这些皮肤不良反应的临床表现,选择适当的药物及时正确地治疗,积极预防不良反应的发生,对确保肿瘤患者治疗的连续性,改善其生活质量有重要的意义.

Epidermal growth factor receptor inhibitors （EGFRIs） have become an important option for the targeted treatment of a variety of tumors.However,EGFRIs may cause a series of adverse skin reactions,such as papulopustular （acneiform） eruption,hair and nail changes,radiation dermatitis,pruritus,xerosis,fissure and oral complications.To recognize the manifestations of adverse skin reactions,give timely and appropriate treatment with proper drugs,and to actively prevent the occurrence of adverse reactions are of great value in ensuring continuation of treatment and improving patients＇ quality of life.