隐花色素蛋白光依赖磁感应机制研究进展

Research Progress of Cryptochromes Light-dependent Magnetoreception Mechanism

隐花色素(Cryptochrome,CRY)蛋白是一种对蓝光敏感的蛋白,在植物中主要调节生长及发育,是果蝇等昆虫光信号的接收者,在哺乳动物中扮演调节生物钟的角色。CRY蛋白作为磁光信号感受器受到广泛关注,其结构中的保守的色氨酸三联体与辅因子黄素腺嘌呤二核苷酸(flavin adenine dinucleotide,FAD)间自由基电子对是CRY蛋白具有光依赖的磁感应功能的关键因素。该文对CRY蛋白的分类及结构特征、光依赖磁感应机制的研究进展进行了综述,并对目前CRY蛋白研究中存在的问题及未来研究方向进行了展望。

Cryptochromes are photosensory receptors mediating light regulation of growth and development in plants, as well as the optical signaling in flies and other insects. Meanwhile it performs functions at the Core of the mammalian circadian clock. Cryptochrome is widely accepted as a magnetoreception receptor, in which a radical pair between conserved tryptophan triad and cofactor flavin adenine dinucleotide plays a central role in light - dependent magnetoreception. It was reviewed in this paper the classification and structures of crypto- chromes and the research progress of eryptochromes light - dependent magnetoreception mechanism, chan｜lenges and questions for future investigation were also discussed.