双氯芬酸含漱液对放射性口腔黏膜炎的止痛效果观察

Analgesic effect of DICLORAL on radiation-induced oral mucositis

目的 :评价双氯芬酸含漱液(DICLORAL)对放射性口腔黏膜炎所引起的疼痛的临床疗效。方法 :将59例因鼻腔NK/T细胞淋巴瘤而接受放疗导致放射性口腔黏膜炎的患者随机分为试验组(30例)和对照组(29例),试验组采用双氯芬酸含漱液,对照组采用复方硼酸含漱液。观察静态疼痛强度和吞咽疼痛强度的改变以及止痛起效时间和维持时间。采用SPSS16.0软件包对数据进行统计学分析。结果:2组的静态疼痛强度和吞咽疼痛强度的改变、止痛起效时间无显著差异(P>0.05),试验组的维持时间显著长于对照组(P<0.05)。结论:双氯芬酸含漱液能有效地缓解和消除放射性口腔黏膜炎引起的疼痛,疗效维持长于复方硼酸含漱液。

PURPOSE： To assess the effects of DICLORAL＇s alleviation of pain caused by radiation-induced oral mucositis. METHODS ：With compound borax solution as a comparative drugs, the solution of DICLORAL was adopted for patients with radiation-induced oral mucositis due to radiotherapy for nasal NK/T cell lymphoma. All 59 patients were randomly divided into 2 groups： experimental group （using DICLORAL） and control group （using Compound Borax Solution）. During the treatment, we observed drugs＇ ability of alleviate oral pain or pain on swallowing, when it worked and how long it could sustain in controlling pain. Statistical analysis was performed using SPSS 16.0 software package. RESULTS： Drugs＇ ability of alleviate oral pain or pain on swallowing and the onset time was not significantly different between the 2 groups （P〉0.05）. Effective duration in experimental group was longer than that in control group （P〈0.05）. CONCLUSIONS： DICORAL can alleviate and cease pain caused by radiation-induced oral mucositis effectively.