乙型病毒性肝炎血清流行病学调查及病毒基因型研究

Epidemiological investigation of viral hepatitis type B and viral genotypes

目的对东莞地区各区域乙型病毒性肝炎的流行现状及病毒基因型进行抽样调查,为东莞地区的乙型肝炎(下称乙肝)防治工作提供科学依据。方法采用集中采集和入户采集相组合的方法,分别在东莞东、南、西、北4个区域共收集1 041例研究对象,根据年龄分组进行志愿者问卷调查和血样采集。结果 1 041例志愿者共诊断出乙肝病毒(HBV)感染318例(30.5%),318例乙型病毒性肝炎患者HBV基因分型为B型229例(72.0%),C型79例(24.8%),D型5例(1.6%),B、C混合型5例(1.6%)。乙肝血清亚型分析结果显示,B型基因中Ba亚型占91.0%,adw2血清型占93.6%;C型基因中C2亚型占92.0%,adrq+血清型占85.0%;东莞地区慢性乙肝患者以B型基因为主,其次是C型基因。B型基因样本中,以Ba亚型、adw2血清型为主;C型基因样本中,以C2亚型、adrq+血清型为主。结论东莞地区乙型病毒性肝炎的流行分布有年龄和地域差异性,自疫苗接种开展以来,HBV感染率得到了明显控制,对其基因分型和流行现状进行进一步研究,可为东莞地区乙肝防治策略的制订提供科学依据。

Objective To investigate the prevalence of the viral hepatitis type B and viral genotypes in Dong-guan area .Methods Centralized collection and home collection were performed for questionnaire survey and blood samples detection in 1 041 subjects of Dongguan area in groups of different ages .Results The infectious rage of hep-atitis B virus （HBV） was 30 .5% （318/1 041） ,including of 72 .0% （229/318） of genotype B ,24 .8% （79/318） of gen-otype C ,1 .6% （5/318） of genotype D ,and 1 .6% （5/318） of mixed genotypes B and C .In different subtypes of B gen-otype ,Ba subtype accounted for 91 .0% and adw2 serotype accounted for 93 .6% .In different subtpes of C genotype , C2 subtype accounted for 92 .0% and adrq＋ serotype accounted for 85 .0% .Patients with chronic hepatitis B was given priority to type B gene in Dongguan ,followed by type C gene .Conclusion The prevalence of hepatitis type B might be with age and area difference in Dongguan area .Further study of HBV genotypes and prevalence status might be helpful for developing strategies to prevent and treatment of hepatitis type B .