人类软骨糖蛋白-39水平与颈动脉粥样硬化斑块及其稳定性的临床观察

Relationship between YKL-40 and carotid atherosclerosis and plaque stability

目的研究人类软骨糖蛋白-39(YKL-40)水平与颈动脉粥样硬化性斑块稳定性间的联系。方法回顾性分析保定市高阳县医院2011年12月至2012年12月收治的65例急性脑梗死患者的临床资料。根据患者CT或MRI诊断结果分为无斑块组(n=14)、稳定斑块组(n=21)和不稳定斑块组(n=30),并选取30例健康体检者作为健康对照组。对各组YKL-40水平进行测定,并进行统计学分析。结果急性脑梗死患者YKL-40水平远远高于健康对照组,差异有统计学意义(P<0.01);脑梗死患者中不稳定斑块组YKL-40水平远远高于稳定斑块组,稳定斑块组YKL-40水平远远高于无斑块组,差异均有统计学意义(P<0.01)。结论脑梗死患者YKL-40水平能表征患者颈动脉粥样硬化的斑块及其稳定性。

Objective To investigate relationship between human cartilage glycoprotein 39 （YKL-40） and sta-bility of carotid atherosclerotic plaque .Methods A total of 65 patients with acute cerebral infarction （ACI） ,treated during Dec .2011 and Dec .2012 ,were divided into without plaque group （14 cases） ,stable plaque group （21 cases） and unstable plaque group （30 cases） ,and 30 healthy subjects were enrolled as control group .Levels of YKL-40 were detected and statistically analyzed .Results Level of YKL-40 in ACI group was significantly higher than control group （P〈0 .01） .YKL-40 level in unstable plaque group was significantly higher than stable plaque group ,and the later was significantly higher than without plaque group （P〈0 .01） .Conclusion Carotid atherosclerosis and plaque stability might be closely related to level of YKL-40 in ACI patients .