阿维A治疗寻常型银屑病的疗效及对血清VEGF、IL-6的影响

Efficacy of Acitretin on Patients with Psoriasis Vulgaris and Its Effect on Serum Vascular Endothelial Growth Factor,Interleukin-6

目的观察阿维A治疗中、重度寻常型银屑病的临床疗效及其对血清血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)水平的影响。方法 32例银屑病患者口服阿维A治疗,疗程8周,治疗前后采用银屑病皮损面积和严重程度指数评分标准(PASI)进行疗效评定;采用酶联免疫吸附试验(ELISA)测定患者治疗前后血清VEGF和IL-6水平并与18例健康对照组比较。结果 32例中、重度寻常型银屑病患者治疗8周后有效率为87.50%;治疗后血清VEGF、IL-6水平明显低于治疗前(P<0.01);银屑病患者血清VEGF、IL-6水平与PASI评分呈正相关(P均<0.01);银屑病患者治疗前、治疗后血清VEGF、IL-6均显著高于健康对照组(P<0.01)。结论阿维A治疗中、重度寻常型银屑病有较好疗效,其作用机制可能与抑制患者血清IL-6、VEGF有关。

Objective To study the therapeutic effect of acitretin on moderate or severe psoriasis vulgaris and effect of acitretin on serum levels of vascular endothelial growth factor （ VEGF ） , interleukin （ IL ）-6 .Methods Thirty-two patients with psoriasis vulgaris were treated with oral acitretin ,and the treatment lasted for 8 weeks.The efficacy of treatment was evaluated by Psoriasis Area and Severity Index （ PASI） scores.The levels of VEGF and IL-6 in serum of patients were detected by enzyme-linked immunosorbent assay （ ELISA ） , and were compared with the healthy controls（18 cases）.Results The effective rate was up to 87.50%in 32 cases of moderate or severe psoriasis vulgaris after 8-week treatment .The serum levels of VEGF and IL-6 after treatment were significantly lower than those before treatment （ P〈0 .01 ） .The serum levels of VEGF and IL-6 correlated with PASI scores positively in psoriasis patients（P〈0.01）.The serum levels of VEGF and IL-6 of psoriasis patients were significantly higher than those of control group before and after treatment （ P 〈0 .01 ） .Conclusion Acitretin has better effect on the treatment of moderate or severe psoriasis vulgaris by inhibiting the serum levels of IL-6 and VEGF.