吸烟对颈动脉功能的影响

Effects of Smoking on Carotid Vascular Function

目的利用超声技术及血管回声跟踪技术(Echo tracking technology,ET)评价男性吸烟者颈动脉弹性功能。方法将符合要求的男性受试者,吸烟者112例,非吸烟者80例,检测各组颈总动脉内中膜厚度(Intima-media thickness,IMT)、并分析动脉硬化参数,包括动脉僵硬系数(Arterial stiffness coefficient,β)、压力-应变弹性系数(Pressure elastic coefficient,Ep)、动脉顺应性(Artery compliance,AC)、膨大指数(Adamkiewicz index,AI)及脉搏波传导速度(Pulse wave velocity,PWV)。结果男性吸烟者双侧颈总动脉窦部和左侧颈总动脉IMT较男性非吸烟者增厚,差异有统计学意义,动脉僵硬系数(β)、压力-应变弹性系数(Ep)、脉搏波传导速度(PWV)增加,膨大指数(AI)及动脉顺应性(AC)下降。结论长期大量吸烟可以导致脂代谢紊乱,并可导致颈总动脉内中膜厚度增加,损伤血管内皮功能导致动脉硬化。

Objective Use of ultrasound and vascular Echo tracking technology （ET） to evaluate the effects of smoking on carotid vascular function. Methods 112 active male smokers and 80 male nonsmokers were enrolled,ultrasound and ET were used to detect the carotid vascular intima-media thickness（IMT）, arterial stiffness coefficient（beta）, pressure elastic coefficient （Ep）, artery compliance（AC）, Adamkiewicz index（AI） and pulse wave velocity（PWV）. Results Compared to the male non-smokers, bilateral carotid sinus and the left common carotid artery intima-media thickness increased in active male smokers, the difference is significant. Arterial stiffness coefficient （β） rised,Pressure elastic coefficient （ Ep ） increased,Pulse wave velocity （ PWV ） accelerated, Adamkiewicz index （ AI ） and Artery compliance（AC） dropped . Conclusion long-term heavy smoking may affect the lipid, leading to abnormal metabolism of blood lipid and endothelial dysfunction, leading to arteriosclerosis.