亮氨酸调节哺乳动物脂肪代谢的研究进展

Leucine: Regulation on Fat Metabolism in Mammals

近年来,大量的体内和体外试验研究表明,亮氨酸可以调节哺乳动物(主要是鼠和人类)的脂肪代谢,主要表现在降低脂肪合成,促进脂肪分解。而添加亮氨酸或者亮氨酸缺乏对脂肪代谢产生影响的作用机制涉及到酶、基因表达和中枢神经系统的调节,且存在明显的差异。因此,本文旨在综述亮氨酸处理对哺乳动物脂肪代谢的影响及相关的作用机制。

Recently,many in vivo and in vitro experiments have shown that the fat metabolism can be regulated by leucine in mammals,especially rodents and humans.Both leucine supplementation and deprivation can affect fat metabolism via different mechanisms that involved in the regulation of enzyme and gene expression,and the central nervous system.Therefore,this paper reviewed the effects of leucine on fat metabolism and related mechanisms that leucine regulates fat metabolism in mammals.