应用能谱CT定量尘肺患者肺内二氧化硅沉积量的研究

Research on quantifying pneumoconiosis lung deposition of silica by energy spectrum CT

目的应用宝石能谱CT测量尘肺患者肺组织内二氧化硅(SiO2)沉积量。方法应用宝石能谱CT扫描一期尘肺和二期尘肺患者共计30例作为研究对象(尘肺组),扫描X线胸片无异常改变的非接尘人员26例作为对照组,分别在主动脉弓顶、气管隆嵴、气管分叉下3 cm附近平面于双背侧肺野外围、双侧肺门旁选择感兴趣区(ROI),应用GSI Viewer浏览器处理图像,进行单能量图像重建,基于SiO2/water测量ROI中SiO2含量,并应用SPSS 13.0统计分析软件进行统计学分析,以P<0.05为差异具有统计学意义。结果尘肺组肺组织内SiO2沉积量为(9.44±2.67)mg/ml,对照组肺组织内SiO2沉积量为(2.06±1.14)mg/ml,组间差异有统计学意义(t=-12.21,P=0.000);尘肺组肺门附近肺组织SiO2沉积量为(9.52±2.54)mg/ml,肺野外围肺组织SiO2沉积量为(9.35±2.67)mg/ml,差异无统计学意义(t=0.690,P=0.933);一期尘肺肺组织SiO2沉积量为(8.20±1.51)mg/ml,二期尘肺肺组织SiO2沉积量为(12.50±1.70)mg/ml,差异有统计学意义(t=-10.31,P=0.000)。结论应用宝石能谱CT扫描获得的单能谱图像可以定量评价肺组织内SiO2沉积量。

Objective To measure silica dioxide（SiO2） deposition in the lung of pneumoconiosis patients by Gem Spectral CT.Methods Applying Gem Spectral CT to analyze a total of thirty phase I-II pneumoconiosis patients and scanning twenty-six persons without dust exposure （X-ray no abnormal change） for comparison. The nearby plane of three cm under aortic arch, carina and tracheal bifurcation was analyzed, and then the lower periphery of bilateral dorsal lung field, neighboring bilateral hilar’s ROI images were processed by GSI Viewer browser in order to reestablish monoenergetic images. The content of ROI＇s SiO2 based on SiO2/water pair was measured according to disparityP〈0.05 by applying SPSS 13.0 statistical analyzing software. The result was significant for statistics.Results The SiO2 deposition of pneumoconiosis patients was （9.44±2.67）mg/ml while SiO2 deposition of the persons without dust exposure was （2.06±1.14）mg/ml. The difference was statistically significant（t=-12.21,P=0.000）. The lung tissue near hilar＇s SiO2 deposition of pneumoconiosis patients was （9.52±2.54）mg/ml; the lung tissue near lower periphery of lung field＇s was （9.35±2.67）mg/ml（t=0.690,P=0.933）, there was no statistical significance. The lung tissue of phaseⅠ pneumoconiosis patients’ SiO2 deposition was （8.20±1.51）mg/ml comparing with phaseⅡ pneumoconiosis patients’ （12.50±1.70）mg/ml. The difference was statistically significant（t=-10.31,P=0.000）.Conclusion Single energy image by Gem Spectral CT can qualify and evaluate SiO2 deposition of lung tissue.