双氯芬酸二乙胺凝胶剂的含量测定

Content Determination of Diclofenac Diethylamine Gel

目的：采用HPLC法测定双氯芬酸二乙胺凝胶剂的含量。方法：以甲醇：4％冰醋酸（70：30）为流动相，CNWC。8色谱柱（150mm×4．6mm，5μm），检测波长为276nm。结果：双氯芬酸钠的测定在51．600-1290．0μg／ml范围内线性关系良好，双氯芬酸钠的平均回收率为101．2％，RSD=1．2％（n=9）。结论：方法简单、灵敏度高，可用于双氯芬酸二乙胺凝胶剂的含量测定。

Objective：The purpose is to develop method for the content determination of Diclofenae Diethylamine Gel. Methods： Separation was performed on a CNW column （150mm×4.6mm,5μm）. The mobile phase consists of methanol：4% acetic acid solution （70：30,v/v）. The UV detection was set at 276nm. Results： Diclofenae diethylamine had a good linear relation in the range of 51.600-1290.0μg/m], the average reeovery of Diclofenae diethylamine was 101,1% and the RSD was 1.2%. Conclusion： The method was simple, sensitive and rapid and it could be used for the determination the content in Diclofenae Diethylamine Gel.