支气管扩张症稳定期的下呼吸道细菌定植研究

Lower airway bacterial colonization in stable phase bronchiectasis disease patient

目的研究支气管扩张症患者下呼吸道细菌定植（LABC）及其与气道阻塞的关系。方法入选明确诊断的支气管扩张症患者40例，于稳定期进行痰细菌定量培养、肺功能检查。结果在40例稳定期支气管扩张症患者中LABC阳性组15例，阴性组25例，提示存在细菌定植，以铜绿假单胞菌为主，并发现LABC阳性组第1秒用力呼气量（FEV1）低于LABC阴性组（P〈0．05），用力肺活量（FVC）及FEV1／FVC两组比较差异无统计学意义（P〉0．05）。结论稳定期支气管扩张症患者存在下呼吸道细菌定植，定植菌以铜绿假单胞菌为主，肺功能损害严重者更容易出现细菌定植，细菌定植可进一步加重气道阻塞。

Objective To investigate the relationship between lower airway bacterial colonization （LABC） existed in stable phase bronchiectasis and to establish the relationship between LABC and airway obstruction in patients with bronchiectasis. Methods A total of 40 patients with sever bronchiectasis in stable phase were included in this study, sputum samples were analyzed for bacterial quantitative culture. Pulmonary function test was evaluated at the same time. Results At the stable phase, fifteen patients were considered LABC colonized. Pseudomonas aeruginosa influenzae was the most important colonized pathogen. And the patients＇ FEV1 with LABC was lower than that without LABC （P 〈 0.05 ） , the difference of FVC and FEV1/FVC between the two groups had no statistical significance （ P 〉 0.05 ）. Conclusions Some patients with clinically stable bronchiectasis has LABC, the lung function more serious, the bacterial colonization easier, and it can further aggravate airway obstruction. damage