TLR4在妊娠异常终止中的作用机制和研究进展

Research Advance and Functional Mechanism on TLR4 in Anomalous Termination of Pregnancy

Toll样受体(toll-like receptors,TLRs)作为一种病原模式识别受体在免疫反应中起着重要的作用。TLR4是最早发现的TLRs成员,它是革兰氏阴性菌胞壁成分脂多糖(lipopolysaccharide,LPS)的识别受体。LPS与TLR4在胞外结合后,通过MyD88依赖和非依赖途径引起炎症反应。TLR4在生殖道炎症反应中具有重要作用,临床上可通过对利用TLR4信号转导通路的阻断来获得治疗效果。作者概述了TLR4的分子结构、组织表达和细胞内信号转导,以及在生殖系统病变状态下的表达,在此基础上提出了TLR4在生殖临床医学应用上可能的意义。

Toll-like receptors （TLRs） as the member of pathogen pattern recognition receptors play important roles in theimmune response. TLR4 is the first discovered member of the TLRs, which is the recognition receptors of lipopolysaccharide（LPS）, the component from cell wall of Gram-negative bacteria. The binding of LPS and TLR4 in the extracellular induce in-flammation by the MyD88-dependent or independent ways. TLR4 plays a pivotal role in the genital tract inflammation, and inclinical treatment, that intracellular signal pathway of TLR4 is blocked by antagonists or drug can achieve therapeutic effects. Inthe article, molecular structure, tissue expression profiles and intracellular signal transduction were described, and the relationship between its expression and reproductive system disease were stated. After that, we propose some suggestions and outlooksin reproductive clinical medicine by regulating the signal pathway of TLR4.