抗病毒治疗慢性乙型肝炎患者肝细胞cccDNA水平的研究
被引量:1
摘要
乙型肝炎病毒(HBV)感染呈世界性流行。HBVcccDNA是HBV复制的原始模板,目前抗病毒治疗药物无法直接清除肝细胞内cccDNA,导致其持续存在肝细胞核内,成为肝炎迁移不愈和复发的根源。本研究对接受抗病毒治疗后的慢性乙型肝炎患者肝细胞cccDNA水平进行检测,现报告如下。
出处
《山西医药杂志》
CAS
2014年第13期1564-1566,共3页
Shanxi Medical Journal
参考文献11
-
1Jiang YF, Ma ZH, Zhao PW, et al. Effect of thymosin-α(1) on T-helper 1 cell and T-helper 2 cell eytokine synthesis in patients with hepatitis B virus e antigen-positive chronic hep- atitis B[J]. J Int MedRes,2010,38:2053-2062.
-
2中国肝病和传染病协会,中国医学联合会.慢性乙型肝炎防治指南[J].中华肝脏病杂志,2011,19(1):1324.
-
3Bowden S, Jackson K, Littlejohn M, et al. Quantification of HBV covalently closed circular DNA from liver tissue by real time PCR[J]. Methods Mol Med,2004,95:41-50.
-
4Belloni L, Allweiss L, Guerrieri F, et al. IFN a inhibits HBV transcription and replication in cell culture and in hu- manized mice by targeting the epigenetic regulation of the nu- clear cecDNA minichromosome[J]. J Clin Inves, 2012,122: 529-537.
-
5Levrero M, Pollicino T, Petersen J, et al. Control of cccD- NA function in hepatitis B virus infection[J]. J Hepatol, 2009, 51: 581-592.
-
6Volz T, Lutgehetmann M, Wachtler P, et al. Impaired in- trahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients[J]. Gastroenterol- ogy, 2007,133 : 843-852.
-
7Thompson AJ, Nguyen T, Iser D, et al. Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepati tis B virus markers[J]. Hepatology, 2010,51 : 1933-1944.
-
8Jaroszewicz J, Calle Serrano B, Wursthorn K, et al. Hepati- tis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective [J]. J Hepatol, 2010, 52: 514-522.
-
9Manesis EK, Papatheodoridis GV, Tiniakos DG, et al. Hep- atitis B surface antigen: relation to hepatitis B replication pa- rameters in HBeAg-negative chronic hepatitis B[J]. J Hepa tol,2011,55: 61-68.
-
10Takkenberg RB, Zaaijer HL, Menting S, et al. Detection of hepatitis B virus covalently closed circular DNA in paraffin- embedded and cryo-preserved liver biopsies of chronic hepati- tis B patients[J]. Eur l Gastroenterol Hepatol, 2010, 22: 952 960.
同被引文献6
-
1QinNi,ZhiChen,Hang-PingYao,Zheng-GangYang,Ke-ZhouLiu,Ling-LingWu.Inhibition of human La protein by RNA interference downregulates hepatitis B virus mRNA in 2.2.15 cells[J].World Journal of Gastroenterology,2004,10(14):2050-2054. 被引量:13
-
2吴建,王际云.拉米夫定联合中药治疗慢性乙型肝炎76例[J].中西医结合肝病杂志,2007,17(3):172-173. 被引量:3
-
3杨德刚,缪晓辉,赵克开,徐文胜,何芳,唐百花.胡黄连总苷抑制乙型肝炎病毒复制作用的体外研究[J].中华传染病杂志,2009,27(3):129-132. 被引量:2
-
4朱晓骏,孙学华,李璐,高月求.灵猫方药物血清体外抗乙肝病毒作用的研究[J].中西医结合肝病杂志,2011,21(6):346-347. 被引量:8
-
5孙学华,朱晓骏,高月求,杨婉凤,李曼,周振华,李璐,刘顺庆,姚军,楼微微.灵猫方联合恩替卡韦治疗慢性乙型肝炎临床研究[J].上海中医药大学学报,2012,26(6):42-44. 被引量:10
-
6高萍,谢朝良.体外抗乙肝病毒研究进展[J].中西医结合肝病杂志,2003,13(1):60-62. 被引量:5
二级引证文献1
-
1LIU Lulu,CHEN Yanxu,LIU Lulu,LI Man,XU Rui,QU Wensheng,YIN Jiye,ZHANG Xin,ZHOU Zhenhua,GAO Yating,NIE Dan,SHAN Junjie,GAO Yueqiu.Chemical characters and protective effect of Baqi Lingmao formula(巴芪灵猫方) on experimental liver injury[J].Journal of Traditional Chinese Medicine,2021,41(6):862-874.
-
1申婷,游晶,范晶华,杨微波,陈和敏.慢性乙型肝炎抗病毒治疗研究进展[J].实用医学杂志,2014,30(3):339-341. 被引量:31
-
2卢建溪,舒欣,曹红.通过干扰素对慢性乙型肝炎发生转阴病例分析[J].医学信息(下旬刊),2009(9):52-53. 被引量:3
-
3王耀宗.慢性乙型肝炎抗病毒治疗药物—拉米夫定的临床应用[J].山东医药,1999,39(11):41-43. 被引量:1
-
4潘映秋.慢性乙型肝炎抗病毒治疗药物的研究进展[J].医学信息(中旬刊),2011,24(7):3413-3414.
-
5王敏.艾滋病抗病毒治疗新进展[J].临床内科杂志,2016,33(2):87-90. 被引量:2
-
6黄睿,魏来.2014年丙型肝炎领域的研究进展[J].中华肝脏病杂志,2015,23(2):81-85. 被引量:10
-
7王宇明.抗病毒治疗药物十二问(下篇)[J].肝博士,2011(2):20-22.
-
8蔡卫民.慢性乙型肝炎的抗病毒治疗药物[J].健康研究,2011,31(6):401-406. 被引量:7
-
9苏静.抗病毒治疗艾滋病48例临床研究[J].蛇志,2010,22(3):223-225.
-
10贾杰,吴彪.慢性乙型病毒性肝炎抗病毒治疗机制的研究现状[J].新医学,2008,39(2):118-120. 被引量:14