低分子肝素钙联合灯盏花素治疗老年肺心病疗效分析

Clinical observation of combined treatment of low molecular weight heparin calcium and breviscapine in elder pulmonary heart disease

目的探讨低分子肝素钙和灯盏花素联用治疗老年肺心病的疗效。方法将2011年5月至2013年6月在该院住院的303例确诊老年肺心病患者分为3组,A组(n=100)、B组(n=102)、C组(n=101)。A组予以常规治疗,B组在常规治疗基础上加用低分子肝素钙,C组在常规治疗基础上给予低分子肝素钙和灯盏花素治疗。观察3组患者治疗后临床症状改善、血气分析和血流动力学的改变。结果 3组患者临床疗效总有效率分别为59.0%、73.5%和90.0%;B、C组患者血气分析和血流动力学治疗后较A组均有改善(P<0.05),C组优于B组(P<0.05)。结论低分子肝素钙和灯盏花素联用能显著改善老年肺心病患者的症状,降低肺动脉压,减轻右心室负荷,改善肺心病的动脉血氧分压、静息状态下平均肺动脉压和血流动力学,且不良反应小。

Objective To explore the clinical therapeutic effect of combined treatment of low molecular weight heparin calcium and breviscapine in elder pulmonary heart disease .Methods 303 patients in elder pulmonary heart disease in the hospital from May 2011 to June 2013 were divided into three groups .100 patients in group A were received the routine therepy ,102 patients of group B were received routine therapy combined with low molecular weight heparin calcium only ,101 patients of group C were received routine therapy combined with low molecular weight heparin calcium and breviscapine .the changes of clinical symptom ,blood gas a-nalysis ,hemorheology in groups before and after treatment were observed .Results The effective rates of group A ,B ,C were 59 .0% ,73 .5% and 90 .0% ,the results showed that the blood gas analysis and hemorheology parameter in groups B and C had more improved than group A （P〈0 .05） ,and better in group C than group B（P〈0 .05） .Conclusion The combined treatment of low molecular weight heparin calcium and breviscapine can decrease the press of lung artery ,relieve the bear of right ventricle and improve the arterial partial pressure of oxygen ,mean pulmonary arterial pressure and hemorheology parameter ,and has less adverse reaction .