Bcl-6共抑制因子样蛋白及E钙黏蛋白在胃癌中的表达及相关性分析

The expression of BCORL1 and E-cadherin in gastric carcinoma and their correlation analysis

目的检测Bcl-6共抑制因子样蛋白1(BCORL1)及E钙黏蛋白(E-cadherin)在胃癌及对应的癌旁组织中的表达情况,分析二者表达的相关性。方法收集58例胃癌及对应癌旁组织,运用免疫组织化学技术检测BCORL1及E-cadherin的表达情况,分析二者表达的相关性。结果 BCORL1在胃癌组织中的表达显著高于对应的癌旁组织(60.3%vs.17.2%,P=0.000),而E-cadherin在胃癌组织中的表达显著低于对应的癌旁组织(27.6%vs.63.8%,P=0.000);BCORL1及E-cadherin表达与肿瘤组织病理分化、浸润深度、淋巴结转移和TNM分期相关(P<0.05);胃癌组织中BCORL1与E-cadherin表达呈负相关(r=-0.571,P=0.002)。结论胃癌组织中BCORL1高表达与恶性临床病理参数相关,并与E-cadherin表达呈负相关,提示BCORL1可能通过转录抑制E-cadherin,促进胃癌进展和转移。

Objective To investigate the expression of BCORL1 and E-cadherin and their correlation analysis in gastric carcino-ma .Methods We freshly collected 58 samples of surgically resected paired gastric carcinoma and normal tumor-adjacent tissues and detected BCORL1 and E-cadherin expression in the samples using immunohistochemical staining .The correlation between BCORL1 and E-cadherin protein expression was analysed .Results The protein expression of BCORL1 in gastric carcinoma tissues was sig-nificantly upregulated compared to those of the normal tumor-adjacent tissues（60 .3% vs .17 .2% ,P=0 .000） ,but expression of E-cadherin in gastric carcinoma tissues was significantly lower than those in the normal tumor-adjacent tissues （27 .6% vs .63 .8% , P=0 .000） .Clinicopathological analysis suggested that EphA2 and E-cadherin protein expression were associated with histopatho-logical differentiation ,depth of invasion ,lymph node metastasis and TNM stage（P〈0 .05） .BCORL1 was significantly negative cor-related with E-cadherin protein in gastric carcinoma（r= -0 .571 ,P=0 .002） .Conclusion The high-expression of BCORL1 is cor-related with malignant clinicopathological characteristics ,and BCORL1 is negative associated with E-cadherin ,suggesting that BCORL1 promotes tumor progression and metastasis through transcriptional regulating E-cadherin in gastric carcinoma .