鹿茸益肾胶囊治疗肾阳虚证阳痿的药效学研究

Pharmacodynamic Study of Lurongyishen Capsules on the Treatment of Impotence with Kidney Yang Deficiency Syndrome

目的:研究鹿茸益肾胶囊治疗肾阳虚证阳痿的药效学机制。方法:观察鹿茸益肾胶囊对去势雄性大鼠阴茎勃起潜伏期的影响,对去势雄性大鼠附性器官和垂体、肾上腺、胸腺、脾脏质量系数的影响,对去势雄性大鼠性腺内分泌激素血清含量的影响,对氢化可的松致阳虚模型小鼠的影响。结果:鹿茸益肾胶囊能够提高去势雄性大鼠阴茎对刺激的兴奋性,显著缩短勃起潜伏期,提高去势雄性大鼠附性器官的质量系数;提高去势雄性大鼠垂体、肾上腺质量系数;降低去势雄性大鼠胸腺、脾脏质量系数;显著升高大鼠血清睾酮(T)、皮质醇(F)含量、显著降低血清促黄体生成素(LH)、促卵泡刺激素(FSH)含量;显著改善阳虚小鼠的阳虚症状,增强生命力。结论:鹿茸益肾胶囊具有温阳益肾的作用,可用于治疗肾阳虚证阳痿、性功能减退。.

Objective： To study the pharmacodynamic mechanism of lurongyishen capsules in the treatment of impotence with kidney yang deficiency syndrome. Methods： To observe the effects of lurongyishen capsules on penile erection latency in castrated male rats, the effects on the accessory sex organs, pituitary, adrenal, thymus and spleen weight coefficient of castrated male rats, the influence on their serum gonadal hormone content and the impact on hydrogen hydrocortisone induced yang deficiency model mice. Results： Lurongyishen capsules can improve the excitation of the penis to stimulation of castrated male rats and significantly shorten the erectile latency, improve the accessory sex organs, pituitary and adrenal weight coefficient, reduce the thymus and spleen weight coefficient, significantly increase rats’ serum testosterone（T） and cortisol （F） levels, decrease serum luteinizing hormone （LH） and follicle-stimulating hormone （FSH） contents, improve yang deficiency syndrome and enhance the vitality of mice. Conclusion： Lurongyishen capsules have a function of reinforcing kidney, and can be used in the treatment of kidney yang deficiency impotence and sexual dysfunction.