雾化吸入高剂量表面激素与全身静脉激素在极重度COPD患者急性加重期的疗效对比观察

Effect Contrast Observation of Aerosol Inhalation of High-dose Surface Hormones and Systemic Intravenous Injection Hormones in the Treatment of Extremely Severe COPD Patients with Acute Exacerbation

目的:对比雾化吸入高剂量表面激素与全身静脉激素治疗极重度AECOPD的临床效果。方法:选取2011年7月-2013年8月笔者所在医收治的74例极重度AECOPD患者,随机分为观察组与对照组,观察组雾化吸入高剂量布地奈德,对照组全身静脉推注波尼松龙,对比观察两组临床效果。结果:两组患者治疗后动脉血气分析情况均明显优于治疗前(P<0.05),但两组治疗后各指标比较差异无统计学意义(P>0.05)。结论:两种方法均具有良好的临床疗效,雾化吸入具有剂量应用较少,药效发挥快的优势,在临床上可替代全身静脉推注对极重度AECOPD患者开展治疗应用。

Objective：To compare the clinical effect of aerosol inhalation of high-dose surface hormones and systemic intravenous injection hormones in the treatment of extremely severe AECOPD.Method：74 cases of severe AECOPD patients treated in author’s hospital from July 2011 to August 2013 were randomly divided into the observation group and the control group,the observation group with high-dose Budesonide aerosol inhalation,the control group with systemic intravenous injection of Prednisolone,compared and observed the clinical effect of the two groups.Result：The arterial blood gas analysis of two groups of patients after treatment were significantly higher than those before treatment（P〈0.05）,but the difference between the two groups was not statistically significant（P〉0.05）. Conclusion：The two methods have good clinical effect,aerosol inhalation with less inhalation dose,and the advantage of efficacy play fast,can be an alternative to systemic intravenous injection of very severe AECOPD patients for therapy in clinical application.