孕妇血型不规则抗体检测对预防新生儿溶血病HDN的临床意义

Clinical Significance of Maternal Blood Irregular Antibody Detection for the Prevention of Irregular Antibodies HDN

目的:探讨孕妇血型不规则抗体检测对于有效预防新生儿溶血病(HDN)的价值。方法:160例孕妇与配偶血型不合且经A/B IgG抗体筛查者列入研究组,进行产前HDN预防性干预;同期160例孕妇与配偶血型不合但主观不同意进行A/B IgG抗体筛查者列入对照组。观察和比较两组新生儿HDN发生率、黄疸出现时间及总胆红素浓度检测结果。结果:研究组HDN发生率明显低于对照组,黄疸出现时间和总胆红素浓度明显低于对照组,两组比较差异均有统计学意义(P<0.05)。结论:孕妇血型不规则抗体的产前早期筛查对于有效预防HDN的发病具有积极作用,可降低HDN的发病率,同时减轻发病患儿的溶血程度,提高新生儿安全性。

Objective：To investigate the value of maternal blood irregular antibody detection for the prevention of irregular antibodies HDN. Method：160 cases of pregnant women with spouse ABO and after A/B IgG antibody screening were included in the study group,prenatal HDN preventive interventions were used. The same period 160 cases of pregnant women with spouse ABO but subjectively not agreed to A/B IgG antibody screening were included in the control group. The incidence of neonatal HDN,jaundice appears time and total bilirubin concentration test results of two groups neonatal were observed and compared.Result：The incidence of HDN of the study group was significantly lower than the control group,the average time and total bilirubin jaundice was significantly lower than the control group,the difference between the two group were all statistically significant（P〈0.05）.Conclusion：Irregular antibodies prenatal maternal blood screening for effective prevention of early onset of HDN has a positive effect,can reduce the incidence of HDN,while reducing the incidence of children with the degree of hemolysis,improve neonatal safety.