老年慢性阻塞性肺疾病血清25-羟维生素D与肺功能及CAT评分关系

The Relationship Among 25-Hydroxy Vitamin D Level in Serum with the Lung Function and CAT Score of Elderly Patients with COPD

目的探讨老年慢性阻塞性肺疾病血清25-羟维生素D水平与其肺功能及CAT评分之间的相关性。方法选取确诊的老年慢性阻塞性肺疾病患者62例,采用自身对照的方法,分别于急性加重期及稳定期检测患者血清25-羟维生素D水平、肺功能,同时进行CAT评分。结果急性加重期与稳定期相比,患者血清25-羟维生素D水平明显下降(P<0.05)。急性加重期及稳定期患者血清25-羟维生素D水平与肺功能指标第1秒用力呼气流量(FEV1)占预计值百分比[FEV1(%)]呈正相关,与CAT评分呈负相关。结论老年COPD患者存在维生素D缺乏,患者血清25-羟维生素D水平与肺功能及CAT评分有关。临床中应关注老年COPD患者血清25-羟维生素D水平,补充维生素D可能对减缓老年COPD急性加重期患者肺功能的下降有一定的临床意义。

Objective To investigate the relationship among 25-hydroxy vitamin D level in serum with the lung function and CAT score of elderly patients with COPD.Methods 62 cases of elderly patients diagnosed with COPD were selected,to inspect their25-hydroxy vitamin D level in serum,lung function and CAT score in both acute exacerbation period and stable period with the application of self control method.Results The 25-hydroxy vitamin D level in serum of the patiems was significantly decreased in acute exacerbation period compared with stable period （P＜0.05）,and the level of 25-hydroxy vitamin D in serum was positively related to the lung function indicators of FEV1 and FEV1 （％）,and negatively related to CAT score.Conclusions The elderly patients with COPD were lack of vitamin D,and the level of 25-hydroxy vitamin D in serum was related to the lung function and CAT score.So we should attach importance to the level of 25-hydroxy vitamin D in serum,and the supplement of vitamin D may have certain clinical significance to the slowing down of the lung function of elderly patients with COPD in acute exacerbation period.