染料木素的心血管保护作用及机制研究进展

Research advance of cardiovascular protection effect and its mechanism of Genistein

染料木素是从大豆、三叶草、葛根等植物中提取出来的异黄酮化合物,为植物雌激素的一种。其化学结构与内源性雌激素相似,能与雌激素胞膜及胞内受体结合发挥作用,如抗肿瘤、神经保护、调节骨代谢与脂代谢、抗肝纤维化、心血管保护及抗氧化等作用。本文主要综述近年来染料木素在抗心律失常、心肌保护、抗动脉粥样硬化等方面的作用及相关机制研究进展。

Genistein is one of phytoestrogen extracted from soybean,shamrock and radix puerariae. Its chemical structure is similar to endogenous estrogen. And genistein can combine with membrane and endocellular estrogen receptor in antitumour,neuroprotection,bone and lipid metabolism regulation,hepatic fibrosis prevention,cardiovascular protection,antioxdation,etc. This study reviews the cardiovascular protection effects and mechanisms of Genistein,including antiarrhythmic,myocardial protection,antiatherosclerosis.