基于温下法治疗急性有机磷农药中毒的疗效观察

Observation of the Clinical Effect of Treatment with Warm and Purgation Method in Acute Organophosphorus Pesticide Poisoning

目的观察大黄附子汤治疗急性有机磷农药中毒(AOPP)的临床疗效。方法将60例AOPP患者随机分为两组,各30例。对照组在洗胃同时给予阿托品和氯解磷定及生命支持等治疗基础上,治疗组给予大黄附子汤,对照组予硫酸镁灌胃导泻,观察两组有效率、首次排便时间、每日排便次数、胆碱酯酶开始恢复时间及其完全恢复时间和住院天数。结果治疗组总有效率为76.67%,对照组的总有效率为63.33%,两组患者疗效相当(P>0.05);治疗组首次排便时间明显短于对照组,治疗组每日排便次数明显多于对照组(P<0.01)。两组胆碱酯酶开始恢复时间相当(P>0.05);胆碱酯酶最终恢复时间治疗组明显短于对照组(P<0.01)。治疗组与对照组相比住院总天数明显减少(P<0.01)。结论大黄附子汤能明显缩短急性有机磷中毒患者首次排便时间,增加排便次数,助于患者尽早排出毒物,缩短患者住院时间。

Objective： To observe the clinical efficacy of Dahuangfuzi Decoction on acute organophosphorus pesticide poisoning（AOPP）. Methods： 60 cases were randomized into treatment group and control group. Each group were 30 cases. Both cases were given gastric lavage while giving atropine and pralidoxime chloride and life-support treatments. On this basis ,the treatment group received Dahuangfuzi Decoction ,and the control group received magnesium sulfate for purgation. There were some indicators contrasted the efficiency rate including the first time of defecation, the numbers of daily defecation,the recovery time of cholinesterase and hospital days of these two groups. Results： The total efficiency rate of the treatment group was 76.67% and that of the control group was 63.33%. There was no significant difference of the efficacy between 2 two groups（P〉 0.05）. The treatment group＇s first time of defecation was earlier and the numbers of daily defecation were more than the control group obviously. There was a significant difference between the two groups（P〈 0.01 ）. There were no significant differences between treatment group and control group in the recovery time of cholinesterase（P〉 0.05）. While in the completely recovery time of cholinesterase,the treatment group was significantly shorter compared with that of the control group（P〈 0.01 ）. The treatment group＇s hospital days was significantly decreased compared with that of the control group. Conclusion： For AOPP patients,Dahuangfuzi Decoction can shorten the first time of defecation and increase the numbers of defecation ,which is helpful for discharging poison and decreasing the hospital days. And it is worth promoting in primary medical institutions.