新辅助化疗治疗进展期胃癌的临床疗效及影响因素

The effect and the related factors analysis of neoadjuvant chemotherapy for advanced gastric cancer

目的探讨新辅助化疗治疗进展期胃癌的临床疗效及影响因素。方法选择进展期胃癌患者60例,随机分为治疗组和对照组,每组30例。对照组患者直接给予手术治疗,治疗组患者进行2个周期的新辅助化疗,随后进行手术治疗,观察两组患者并发症及术后生存率情况。结果治疗组患者根治切除术的比例明显高于对照组,姑息性切除术比例明显低于对照组,差异均有统计学意义(P<0.05)。ⅢA期和肿瘤<6cm的患者有效率高于ⅢB期和肿瘤≥6cm的患者有效率,但差异无统计学意义(P>0.05)。结论新辅助化疗治疗进展期胃癌是一个有效且副作用较小的方案,肿瘤分期及肿瘤大小可能是影响新辅助化疗的因素。

Objective To investigate the clinical effect of neoadjuvant chemotherapy for advanced gastric cancer. Methods 60 patients with advanced gastric cancer were randomly divided into the treat- ment group and control group （30 cases in each group）. The control group was treated with operation, the treatment group neoadjuvant chemotherapy for 2 cycles before operation. The survival rate and complications of two groups were observed. Results Radical resection rate in treatment group was significantly higher than that of the control group, palliative resection was significantly lower than that of the control group, The differences were statistically significant（ P 〈 0. 05 ）. Effective rate of patients with tumor stage III A stage and tumors 〈 6cm was higher than that of III B stage and tumor≥6cm, but no statistical significant differences were observed （P 〉 0. 05）. Conclusion Neoadjuvant chemotherapy was an effective and well-tolerated reg- imen for advanced gastric cancer, tumor stage and tumor size may be influence factors of new adjuvant chem- otherapy.