不同介入模式治疗肝癌的疗效分析

Efficacy of different modes of intervention in the treatment of liver cancer

目的探讨不同介入模式治疗肝癌的疗效。方法选取收治的原发性肝癌患者300例,根据介入治疗方式随机分为A组、B组和C组,每组100例。其中A组患者采用肝动脉化疗栓塞术(TACE),B组患者采用肝门静脉化疗栓塞(PVCE)治疗,C组患者在A、B组患者治疗方法基础上行经皮肝穿刺乙醇消融(PEI)治疗,比较3组患者治疗后肝功能检查指标、总有效率及不良反应。结果C组患者治疗有效率为43.0%,明显高于A组(23.0%)和B组(29.0%)患者,差异有统计学意义(P<0.05)。C组患者甲胎蛋白变化显著多于A、B两组,差异有统计学意义(P<0.05)。A、B、C组患者并发症发生情况比较,差异无统计学意义(P>0.05);C组患者丙氨酸转氨酶和白蛋白水平与A、B两组患者比较,差异有统计学意义(P<0.05)。结论 TACE、PVCE联合PEI治疗对肝癌患者有显著疗效,可有效控制病情,缓解症状,值得推广。

Objective To explore the curative effect of different modes of intervention treatment of liver cancer. Methods 300 patients with primary liver cancer were selected and divided into group A, group B and group C （ 100 cases respectively） according to modes of intervention treatment. Group A re- ceived embolization treatment with pirarubicin, ultra fluid lipiodol emulsion and gelfoam particles, Group B hepatic portal vein embolization, and Group C PEI on the basis of group A and B. Liver function, the total ef- fective rate and adverse reactions were compared. Results The direct curative effect of group C was signifi- cantly better than that of group A and B （ P 〈 0. 05 ）. The alpha-fetoprotein change of group C was signifi- cantly more than the number of group A and B （P 〈 0. 05 ）. There were no significant differences in compli- cation incidence among the three groups （ P 〉 0.05 ）. Liver functions of group C was significantly different from those of group A and B （ P 〈 0.05 ）. Conclusion Combined treatment of TACE, PEI and PVCE has significant curative effect in patients with liver cancer, effectively control diseases, alleviate the symptoms, which is worthy of promotion.