重性抑郁障碍易感基因EHD3与疾病认知功能相关

Association between EHD3 Gene and the Cognitive Function of Patients with Major Depressive Disorder

目的探讨EHD3基因与重性抑郁障碍(MDD)患者认知功能的相关性。方法以47例MDD患者与40例正常对照者为研究对象,分析其认知功能的差异,然后将MDD患者的各项量表得分作为数量性状,采用UNPHASED软件的数量性状模块,分析认知功能与EHD3基因多态性的相关性。结果 MDD组WAIS-RC和WMS-R量表的各项评分均显著低于正常对照组(P均<0.05)。EHD3基因的rs3769621等位基因及基因型分别与WAIS-RC图形拼凑原始分(χ2=10.561,P=0.001;χ2=7.922,P=0.019)和图形拼凑量表分(χ2=12.627,P=0.00038;χ2=11.775,P=0.0027),以及WMS-R心智(1-100)原始分(χ2=8.762,P=0.003;χ2=17.399,P=0.00016)和心智(1-100)量表分(χ2=10.356,P=0.001;χ2=14.958,P=0.00056)显著相关;经过Bonferroni法校正后,上述结果差异仍显著。结论在中国北方汉族人群中,EHD3基因可能与MDD认知功能内表型相关。

Objective To analyze the potential association between the EHD3 gene and the cognitive function of patients with major depressive disorder （MDD）.Methods A total of 47 MDD patients and 40 healthy controls were enrolled in this study.After their cognitive functions were analyzed,the scores of the MDD patients were used as the quantitative traits; by using the quantitative trait module in the UNPHASED soft ware,we analyzed the potential association of the cognitive traits with the EHD3 gene.Results The cognitive scores （WAIS-RC and WMS-R） of MDD patients were significantly lower than those of controls （P ＜ 0.05）.The rs3769621 allele and genotype of EHD3 gene were significantly associated with the raw score and scaled score ofWAIS-RC （x2=10.561,P=0.001; x2=7.922,P=0.019; x2=12.627,P=0.00038; x2 =11.775,P=0.0027） andWMS-R （x2=8.762,P=0.003; x2=17.399,P=0.00016; x2=10.356,P =0.001 ; x2 =14.958,P =0.00056）.Such associations remained statistically significant after Bonferroni correction.Conclusion The EHD3 gene may be associated with the endophenotype of cognitive function in MDD patients.